An overview of vaccine development for COVID-19

被引：38

作者：

Shahcheraghi, Seyed H. ^{[1
]}

Ayatollahi, Jamshid ^{[1
]}

Aljabali, Alaa A. A. ^{[2
]}

Shastri, Madhur D. ^{[3
]}

Shukla, Shakti D. ^{[4
]}

Chellappan, Dinesh K. ^{[5
]}

Jha, Niraj K. ^{[6
]}

Anand, Krishnan ^{[7
,8
]}

Katari, Naresh K. ^{[9
]}

Mehta, Meenu ^{[10
,12
]}

Satija, Saurabh ^{[10
,12
]}

Dureja, Harish ^{[11
]}

Mishra, Vijay ^{[12
]}

Almutary, Abdulmajeed G. ^{[13
]}

Alnuqaydan, Abdullah M. ^{[13
]}

Charbe, Nitin ^{[14
]}

Prasher, Parteek ^{[15
]}

Gupta, Gaurav ^{[16
]}

Dua, Kamal ^{[17
]}

Lotfi, Marzieh ^{[18
,19
]}

Bakshi, Hamid A. ^{[20
]}

Tambuwala, Murtaza M. ^{[20
]}

机构：

[1] Shahid Sadoughi Univ Med Sci, Shahid Sadoughi Hosp, Infect Dis Res Ctr, Yazd, Iran

[2] Yarmouk Univ, Dept Pharmaceut & Pharmaceut Technol, Irbid, Jordan

[3] Univ Tasmania, Sch Pharm & Pharmacol, Hobart, Tas, Australia

[4] Univ Newcastle, Sch Med & Publ Hlth, Prior Res Ctr Hlth Lungs, Callaghan, NSW, Australia

[5] Int Med Univ, Sch Pharm, Dept Life Sci, Kuala Lumpur, Malaysia

[6] Sharda Univ, Sch Engn & Technol, Dept Biotechnol, Greater Noida, Uttar Pradesh, India

[7] Univ Free State, Fac Hlth Sci, Sch Pathol, Dept Chem Pathol, Bloemfontein, South Africa

[8] Univ Free State, Natl Hlth Lab Serv, Bloemfontein, South Africa

[9] GITAM Deemed Univ, Sch Sci, Dept Chem, Hyderabad 502329, India

[10] Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, Ultimo, NSW 2007, Australia

[11] Maharshi Dayanand Univ, Fac Pharmaceut Sci, Rohtak, Haryana, India

[12] Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara 144411, Punjab, India

[13] Qassim Univ, Coll Appl Med Sci, Dept Med Biotechnol, Buraydah, Saudi Arabia

[14] Pontificia Univ Catolica Chile, Fac Quim & Farm, Dept Quim Organ, Av Libertador Bernardo OHiggins, Santiago 340, Region Metropol, Chile

[15] Univ Petr & Energy Studies, Dept Chem, Dehra Dun 248007, Uttarakhand, India

[16] Suresh Gyan Vihar Univ, Sch Pharmaceut Sci, Jaipur, Rajasthan, India

[17] Univ Technol Sydney, Grad Sch Hlth, Dept Pharm, Ultimo, NSW 2007, Australia

[18] Shahid Sadoughi Univ Med Sci, Sch Med, Dept Med Genet, Yazd, Iran

[19] Shahid Sadoughi Univ Med Sci, Reprod Sci Inst, Abort Res Ctr, Yazd, Iran

[20] Ulster Univ, Sch Pharm & Pharmaceut Sci, Coleraine BT52 1SA, Londonderry, North Ireland

来源：

THERAPEUTIC DELIVERY | 2021年 / 12卷 / 03期

关键词：

COVID-19; vaccines; SARS-CoV-2; SPIKE PROTEIN; POTENTIAL VACCINES; SARS; COV; THERAPEUTICS; STRATEGIES; RELEVANCE; LESSONS; TARGET;

D O I：

10.4155/tde-2020-0129

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The COVID-19 pandemic continues to endanger world health and the economy. The causative SARS-CoV-2 coronavirus has a unique replication system. The end point of the COVID-19 pandemic is either herd immunity or widespread availability of an effective vaccine. Multiple candidate vaccines - peptide, virus-like particle, viral vectors (replicating and nonreplicating), nucleic acids (DNA or RNA), live attenuated virus, recombinant designed proteins and inactivated virus - are presently under various stages of expansion, and a small number of vaccine candidates have progressed into clinical phases. At the time of writing, three major pharmaceutical companies, namely Pfizer and Moderna, have their vaccines under mass production and administered to the public. This review aims to investigate the most critical vaccines developed for COVID-19 to date.

引用

页码：235 / 244

页数：10

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