Retinal prostheses in degenerative retinal diseases

被引：21

作者：

Lin, Tai-Chi ^{[1
,2
]}

Chang, Hua-Ming ^{[3
,4
]}

Hsu, Chih-Chien ^{[1
,2
]}

Hung, Kuo-Hsuan ^{[2
,5
]}

Chen, Yan-Ting ^{[2
,6
,7
]}

Chen, Szu-Yu ^{[3
]}

Chen, Shih-Jen ^{[1
]}

机构：

[1] Taipei Vet Gen Hosp, Dept Ophthalmol, Taipei 112, Taiwan

[2] Natl Yang Ming Univ, Inst Clin Med, Taipei 112, Taiwan

[3] Natl Cent Univ, Dept Opt & Photon, Taoyuan, Taiwan

[4] Bade Vet Home, Taoyuan, Taiwan

[5] Natl Yang Ming Univ Hosp, Dept Ophthalmol, Yilan, Taiwan

[6] Changhua Christian Hosp, Dept Ophthalmol, Changhua, Taiwan

[7] Cent Taiwan Univ Sci & Technol, Dept Optometry, Taichung, Taiwan

来源：

JOURNAL OF THE CHINESE MEDICAL ASSOCIATION | 2015年 / 78卷 / 09期

关键词：

age-related macular degeneration; epiretinal implants; retinal prosthesis; retinitis pigmentosa; subretinal implants; MORPHOMETRIC-ANALYSIS; RETINITIS-PIGMENTOSA; VISION; IMPLANTS; EXPLANTATION; STIMULATION; EYES;

D O I：

10.1016/j.jcma.2015.05.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Degenerative retinal diseases may lead to significant loss of vision. Age-related macular degeneration (AMD) and retinitis pigmentosa (RP), which eventually affect the photoreceptors, are the two most common retinal degenerative diseases. Once the photoreceptorcells are lost, there are no known effective therapies for AMD or RR The concept of retinal prosthesis is to elicit neural activity in the remaining retinal neurons by detecting light and converting it into electrical stimuli using artificial devices. Subretinal, epiretinal, and other retinal prostheses implants are currently designed to restore functional vision in retinal degenerative diseases. In this review, we have summarized different types of retinal prostheses, implant locations, and visual outcomes. Our discussions will further elucidate the results from clinical trials, and the challenges that will need to be overcome to more efficaciously assist patients with AMD and RP in the future. Copyright (C) 2015 Elsevier Taiwan LLC and the Chinese Medical Association. All rights reserved.

引用

页码：501 / 505

页数：5

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