Objective The educational objectives of this continuing medical education activity are for the reader to exercise, self-assess, and improve skills in diagnostic radiology with regard to the imaging evaluation of large airway disease and understanding the basics of CT virtual endoscopy techniques as well as their limitations. Conclusion The articles in this activity review the imaging evaluation of large airway disease and the basics and limitations of CT virtual endoscopy. INTRODUCTION This self-assessment module on imaging evaluation of large airway disease has an educational component and a self-assessment component. The educational component consists of three required articles that the participant should read. The self-assessment component consists of 10 multiple-choice questions with solutions. All of these materials are available on the ARRS Website (www.arrs.org). To claim CME and SAM credit, each participant must first order the CME activity, then enter his or her responses to the questions online. EDUCATIONAL OBJECTIVES By completing this educational activity, the participant will: A. Exercise, self-assess, and improve his or her understanding of the evaluation of large airway disease. B. Understand the basics of CT virtual endoscopy techniques and how the images are produced. C. Be able to name some disease entities of the large airways that may be further evaluated with CT virtual endoscopy. D. Learn some limitations of CT virtual endoscopy. REQUIRED READING 1. Thomas BP, Strother MK, Donnelly EF, Worrell JA. CT virtual endoscopy in the evaluation of large airway disease: review. AJR 2009; 192[suppl]: S20-S30 2. Summers RM, Shaw DJ, Shelhamer JH. CT virtual bronchoscopy of simulated endobronchial lesions: effect of scanning, reconstruction, and display settings and potential pitfalls. AJR 1998; 170: 947-950 3. Prince JS, Duhamel DR, Levin DL, Harrell JH, Friedman PJ. Nonneoplastic lesions of the tracheobronchial wall: radiologic findings with bronchoscopic correlation. RadioGraphics 2002; 22: S215-S230 INSTRUCTIONS 1. Complete the educational and self-assessment components included in this issue. 2. Visit www.arrs.org 3. Order the online SAM as directed. (The SAM must be ordered to be accessed even though the activity is free to ARRS members.) 4. The SAM can be accessed at www.arrs.org under the Lifelong Learning link. 5. Answer the questions online to obtain SAM credit.