Double umbilical cord blood transplantation

被引：101
|
作者：
Majhail, Navneet S.
Brunstein, Claudio G.
Wagner, John E. [1 ]
机构：
[1] Univ Minnesota, Dept Pediat, Bone & Marrow Transplant Program, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Dept Med, Blood & Marrow Transplant Program, Minneapolis, MN 55455 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2006年 / 18卷 / 05期
关键词：
D O I：
10.1016/j.coi.2006.07.015
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Unrelated umbilical cord blood (UCB) is an alternative donor source for allogeneic haematopoietic cell transplantation and, compared with unrelated donor bone marrow, has the advantages of rapid availability, greater tolerance of HLA disparity and lower incidence of severe graft-versus-host disease. Graft cell dose is an important determinant of haematopoietic recovery and overall outcome following UCB transplantation, and the limited cell dose of single UCB units has been a major barrier to its more widespread use. Transplantation with two unrelated UCB units is feasible, safe and effective and can overcome the limitation of cell dose of single UCB units.
引用
收藏
页码：571 / 575
页数：5
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