Sex differences in prefrontal volume with aging and Alzheimer's disease

被引：16
|
作者：
Salat, DH
Stangl, PA
Kaye, JA
Janowsky, JS
机构：
[1] Oregon Hlth Sci Univ, Dept Behav Neurosci, Portland, OR 97201 USA
[2] Oregon Hlth Sci Univ, Dept Neurol, Portland, OR 97201 USA
[3] Oregon Hlth Sci Univ, Portland Vet Affairs Med Ctr, Portland, OR 97201 USA
来源：
NEUROBIOLOGY OF AGING | 1999年 / 20卷 / 06期
关键词：
frontal lobe; prefrontal; sex characteristics; aging; aged; Alzheimer's disease; magnetic resonance imaging; gray matter; human;
D O I：
10.1016/S0197-4580(99)00067-6
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
We used volumetric magnetic resonance imaging to examine sex differences in prefrontal tissue volumes of healthy aged and patients with Alzheimer's disease (AD). Healthy subjects had greater total prefrontal volume than AD, and men had greater total prefrontal volume than women (ps less than or equal to 0.02). This was true for both gray and white matter volumes. There were no interactions between group and sex for total prefrontal volume. An exploratory analysis of each group suggested that sex differences in both gray and white matter in healthy aging are not sustained in AD. (C) 2000 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：591 / 596
页数：6
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