Hierarchical Self-Assembly of Amino Acid Derivatives into Enzyme-Responsive Luminescent Gel

被引：6
|
作者：
Li, Yibao [1 ]
Peng, Yu [1 ]
Liu, Wei [1 ]
Fan, Yulan [1 ]
Wu, Yongquan [1 ]
Li, Xun [1 ]
Fan, Xiaolin [1 ]
机构：
[1] Gannan Normal Univ, Key Lab Organopharmaceut Chem, Ganzhou 341000, Peoples R China
来源：
CHEMOSENSORS | 2017年 / 5卷 / 01期
基金：
中国国家自然科学基金;
关键词：
hydrogel; amylase-response; hydrogen bond; drug delivery; POLYMERIC SUPRA-AMPHIPHILES; DRUG-DELIVERY; AMYLOID FIBRILS; BUILDING-BLOCKS; HYDROGELS; SUPERAMPHIPHILE; DESIGN; MICELLES; ACCEPTOR; COMPLEX;
D O I：
10.3390/chemosensors5010006
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
In this study, a novel three-component hydrogel has been designed and fabricated via hierarchical self-assembly by amino acid derivative (N,N-diphenylalanine-3,4,9,10-tetracarboxylic diimide (NPPD)), riboflavin (RF) and -cyclodextrin (-CD). These molecules were aggregated to form some fibrous structures based on hydrogen bond and - stacking. The results show that the hydrogel has a specific response to -amylase and the fluorescence disappears once hydrolyzed. Therefore, this multi-component hydrogel has potential application in the field of drug delivery.
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页数：8
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