Protective role of endothelial nitric oxide synthase

被引：314

作者：

Albrecht, EWJA

Stegeman, CA

Heeringa, P

Henning, RH

van Goor, H

机构：

[1] Univ Groningen Hosp, Dept Pathol & Lab Med, NL-9713 GZ Groningen, Netherlands

[2] Univ Groningen Hosp, Dept Nephrol, NL-9713 GZ Groningen, Netherlands

[3] Univ Maastricht, Dept Immunol, Maastricht, Netherlands

[4] Univ Groningen Hosp, Dept Clin Pharmacol, NL-9713 GZ Groningen, Netherlands

来源：

JOURNAL OF PATHOLOGY | 2003年 / 199卷 / 01期

关键词：

nitric oxide; endothelial nitric oxide synthase; endothelium; endothelial dysfunction; vascular tone; knockout mice; pharmacological inhibition;

D O I：

10.1002/path.1250

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Nitric oxide is a versatile molecule, with its actions ranging from haemodynamic regulation to anti-proliferative effects on vascular smooth muscle cells. Nitric oxide is produced by the nitric oxide synthases, endothelial NOS (eNOS), neural NOS (nNOS), and inducible NOS (iNOS). Constitutively expressed eNOS produces low concentrations of NO, which is necessary for a good endothelial function and integrity. Endothelial derived NO is often seen as a protective agent in a variety of diseases. This review will focus on the potential protective role of eNOS. We will discuss recent data derived from studies in eNOS knockout mice and other experimental models. Furthermore, the role of eNOS in human diseases is described and possible therapeutic intervention strategies will be discussed. Copyright (C) 2002 John Wiley Sons, Ltd.

引用

页码：8 / 17

页数：10

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