Dinuclear zinc cooperative catalytic three-component reactions for highly enantioselective synthesis of 3,3′-dihydrofuran spirooxindoles

被引：31
|
作者：
Miao, Yu-Hang [1 ]
Hua, Yuan-Zhao [1 ]
Wang, Min-Can [1 ]
机构：
[1] Zhengzhou Univ, Coll Chem & Mol Engn, 75 Daxue St, Zhengzhou 450052, Henan, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2019年 / 17卷 / 30期
关键词：
FRIEDEL-CRAFTS ALKYLATION; CASCADE REACTIONS; DIASTEREOSELECTIVE SYNTHESIS; ASYMMETRIC COPOLYMERIZATION; MULTICOMPONENT REACTIONS; MICHAEL ADDITIONS; ALDOL REACTION; DIELS-ALDER; KNOEVENAGEL; CONSTRUCTION;
D O I：
10.1039/c9ob01233h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new dinuclear zinc cooperative catalytic enantioselective three-component reaction via a domino Knoevenagel /Michael/cyclization sequence has been developed. A series of chiral 3,3 '-dihydrofuran spirooxindoles are obtained in excellent yields (up to 99%) and enantioselectivities (up to 99% ee). In addition, the reaction is carried out smoothly on a gram scale under mild conditions.
引用
收藏
页码：7172 / 7181
页数：10
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