Efficacy of Topical 5% Acyclovir-1% Hydrocortisone Cream (ME-609) for Treatment of Herpes Labialis: a systematic review

被引：5
|
作者：
Da Rosa, Maria Ines [1 ]
Souza, Sueli L. [1 ]
De Farias, Bruna F. [1 ]
Pires, Patricia D. S. [2 ]
Dondossola, Eduardo R. [1 ]
Dos Reis, Maria Eduarda F. [3 ]
机构：
[1] Univ Extremo Sul Catarinense, Lab Epidemiol, BR-88806000 Criciuma, SC, Brazil
[2] Univ Extremo Sul Catarinense, Dent, Univ Extreme South Santa Catarina, BR-88806000 Criciuma, SC, Brazil
[3] Univ Extremo Sul Catarinense, Lab Epidemiol, Vet Med, BR-88806000 Criciuma, SC, Brazil
来源：
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS | 2015年 / 87卷 / 02期
关键词：
Acyclovir; Herpes Labialis; Hydrocortisone; ME-609; Systematic Review;
D O I：
10.1590/0001-3765201520140701
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We performed a systematic review with the objective of verifying the efficacy of topical use 5% Acyclovir-1% Hydrocortisone cream compared to the placebo group for herpes simplex labialis treatment. We performed a literature search using MEDLINE, Embase, BIOSIS, LILACS, Scopus, Grey literature, the Cochrane Central Register of Controlled Trials, the ISI Web of Science and IBECS from 1990 to June 2014. We reported the outcomes using relative risk (RR) with 95% confidence intervals. The literature search yielded 180 potentially relevant publications. Reviews of the reference lists yielded two further citations. Among these papers, two were considered eligible for inclusion in this review. Both trials included 1,213 patients. A meta-analysis of these studies showed a RR = 0.77, (95% CI 0.70-0.86; p<0.001). This result suggests that an early episodic treatment with the combination of an antiviral and a steroid is beneficial for herpes simplex labialis treatment.
引用
收藏
页码：1415 / 1420
页数：6
相关论文
共 25 条
  • [1] Double-blind, randomized, placebo-controlled study of topical 5% acyclovir-1% hydrocortisone cream (ME-609) for treatment of UV radiation-induced herpes labialis
    Evans, TG
    Bernstein, DI
    Raborn, GW
    Harmenberg, J
    Kowalski, J
    Spruance, SL
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (06) : 1870 - 1874
  • [2] The Role of Topical 5% Acyclovir and 1% Hydrocortisone Cream (Xerese™) in the Treatment of Recurrent Herpes Simplex Labialis
    Hull, Christopher M.
    Brunton, Stephen
    [J]. POSTGRADUATE MEDICINE, 2010, 122 (05) : 1 - 6
  • [3] Efficacy of 86C (acyclovir) cream 5% compared with Zovirax(R) (acyclovir) cream 5% in the treatment of recurrent herpes labialis
    Ottevanger, V
    Larsen, J
    Hoybye, S
    Eskerod, O
    [J]. CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, 1996, 57 (04): : 243 - 250
  • [4] Safety and Tolerability of Combination Acyclovir 5% and Hydrocortisone 1% Cream in Adolescents with Recurrent Herpes Simplex Labialis
    Strand, Anders
    Boettiger, Disa
    Gever, Larry N.
    Wheeler, William
    [J]. PEDIATRIC DERMATOLOGY, 2012, 29 (01) : 105 - 110
  • [5] HYDROCORTISONE IN ACYCLOVIR 5%/ HYDROCORTISONE 1% CREAM DOES NOT ADVERSELY AFFECT HEALING TIME IN IMMUNOCOMPROMISED PATIENTS WITH RECURRENT HERPES SIMPLEX LABIALIS
    Olin, Jason T.
    Tyring, Stephen K.
    Lin, Tina
    [J]. JOURNAL OF GENERAL INTERNAL MEDICINE, 2012, 27 : S213 - S213
  • [6] Comparison of new topical treatments for herpes labialis - Efficacy of penciclovir cream, acyclovir cream, and n-docosanol cream against experimental cutaneous herpes simplex virus type 1 infection
    McKeough, AB
    Spruance, SL
    [J]. ARCHIVES OF DERMATOLOGY, 2001, 137 (09) : 1153 - 1158
  • [7] Efficacy of photodynamic therapy on the treatment of herpes labialis: A systematic review
    Lotufo, Monica Andrade
    Ratto Tempestini Horliana, Anna Carolina
    Santana, Thalita
    de Queiroz, Aline Campos
    Gomes, Andrea Oliver
    Motta, Lara Jansiski
    Mesquita Ferrari, Raquel Agnelli
    dos Santos Fernandes, Kristianne Porta
    Bussadori, Sandra Kalil
    [J]. PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2020, 29
  • [8] The efficacy of acyclovir 5%/hydrocortisone 1% cream by age: Post hoc analysis
    Hull, C. M.
    Gordon, R.
    Olin, J. T.
    Tyring, S. K.
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2012, 132 : S85 - S85
  • [9] EFFICACY OF TOPICAL ACYCLOVIR CREAM IN 1ST AND RECURRENT EPISODES OF GENITAL HERPES
    KINGHORN, GR
    TURNER, EB
    BARTON, IG
    POTTER, CW
    BURKE, CA
    FIDDIAN, AP
    [J]. ANTIVIRAL RESEARCH, 1983, 3 (5-6) : 291 - 301
  • [10] HERPES LABIALIS TREATMENT WITH ACYCLOVIR 5-PERCENT MODIFIED AQUEOUS CREAM - A DOUBLE-BLIND, RANDOMIZED TRIAL
    RABORN, GW
    MCGAW, WT
    GRACE, M
    PERCY, J
    SAMUELS, S
    [J]. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, 1989, 67 (06): : 676 - 679
123