Supramolecular aggregates formed by sulfadiazine and sulfisomidine inclusion complexes with α-and β-cyclodextrins

Sulfadiazine (SDA) and sulfisomidine (SFM) inclusion complexes with two cyclodextrins (alpha-CD and beta-CD) are studied in aqueous as well as in solid state. The inclusion complexes are characterized by UV-visible, fluorescence, time correlated single photon counting, FTIR, DSC, PXRD and H-1 NMR techniques. The self assembled SDA/CD and SFM/CD inclusion complexes form different types of nano and microstructures. The self assembled nanoparticle morphologies are studied using SEM and TEM techniques. SDA/alpha-CD complex is formed hierarchal morphology, SDA/beta-CD and SFM/beta-CD complexes form the nanosheet self assembly. However, SFM/alpha-CD complex forms nanoporous sheet self assembly, van der Waals, hydrophobic and hydrogen bonding interaction play a vital role in the self assembling process. (C) 2014 Elsevier B.V. All rights reserved.