Anti-inflammatory and anti-pyretic properties of Spirulina platensis and Spirulina lonar: A comparative study

被引:0
|
作者
Somchit, Muhammad Nazrul [1 ]
Mohamed, Nor Azura [1 ]
Ahmad, Zuraini [1 ]
Zakaria, Zainul Amiruddin [1 ]
Shamsuddin, Lokman [2 ]
Fauzee, Mohd Sofian Omar [3 ]
Kadir, Arifah Abdul [4 ]
机构
[1] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Biomed Sci, UPM Serdang, Selangor Darul Ehsan, Malaysia
[2] Univ Ind Selangor, Shah Alam, Selangor, Malaysia
[3] Northern Univ Malaysia, Sintok, Kedah, Malaysia
[4] Univ Putra Malaysia, Fac Vet Med, UPM Serdang, Selangor Darul Ehsan, Malaysia
关键词
Spirulina platensis; Spirulina lonar; anti-pyretic; Brewer's Yeast; anti-inflammation; Prostaglandin E-2; C-PHYCOCYANIN; AQUEOUS EXTRACT; ACETIC-ACID; IN-VITRO; RATS; ANTIOXIDANT; ETHANOL;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Spirulina spp. is a blue-green algae belongs to the family of Oscillatoriaceae, which having diverse biological activity. The aim of this current study was to evaluate and compare the anti-pyretic and anti-inflammatory activity of Spirulina platensis/SP and Spirulina lonar/SL extracts. In the anti-pyretic study, the ability to reduce the rectal temperature of rats induced pyrexia with 2g/kg Brewer's Yeast (BY) was performed. Rats were dosed either 2 or 4 mg/kg SP or SL. Rectal temperature was taken every hour for 8 hours. Results shown that there were significant dose-dependent (p<0.05) reduction of both treatments. However, SP treatment revealed faster reduction in rectal temperature. For anti-inflammatory activity, the reduction in the volume of paw edema induced by Prostaglandin E-2 (100 IU/rat intraplantar) was measured. Rats were dosed orally with 2 or 4 mg/kg SP or SL. The paw edema was measured every 30 minutes for 4 hours using plethysmometer. Results had shown a significant dose dependent reduction in diameter of paw edema (p<0.05). The finding suggests that SP and SL extracts have anti-pyretic and anti-inflammatory properties. However, SP was found to be more effective than SL as anti-pyretic and anti-inflammatory agent.
引用
收藏
页码:1277 / 1280
页数:4
相关论文
共 50 条
  • [1] STUDY OF ANTI-INFLAMMATORY, ANALGESIC AND ANTI-PYRETIC PROPERTIES OF NONACHLAZIN
    KAVERINA, NV
    KRUPINSKAYA, I
    PIDEVICH, IN
    SOBANSKY, G
    DEMINA, LM
    TSEBO, V
    MAZUR, Y
    [J]. FARMAKOLOGIYA I TOKSIKOLOGIYA, 1980, 43 (03): : 317 - 319
  • [2] LUMINESCENCE PROPERTIES OF SOME ANTI-INFLAMMATORY AND ANTI-PYRETIC DRUGS
    MILLER, JN
    PHILLIPPS, DL
    BURNS, DT
    BRIDGES, JW
    [J]. TALANTA, 1978, 25 (01) : 46 - 49
  • [3] COMBINED ASSAY FOR ANTI-PYRETIC AND ANTI-INFLAMMATORY ACTIVITIES
    WHITEHOUSE, MW
    [J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 1979, 6 (06) : 705 - 705
  • [4] A COMPARATIVE-STUDY OF ANTI-INFLAMMATORY, ANALGESIC AND ANTI-PYRETIC ACTION OF ANTI-TUMOR DRUGS
    TRINUS, FP
    CHERNOV, VA
    RYABUKHA, TK
    SHARYKINA, NI
    [J]. VOPROSY ONKOLOGII, 1980, 26 (05) : 49 - 54
  • [5] Anti-pyretic, anti-inflammatory and anti-diarrhoeal properties of Faidherbia albida in rats
    Tijani, A. Y.
    Uguru, M. O.
    Salawu, O. A.
    [J]. AFRICAN JOURNAL OF BIOTECHNOLOGY, 2008, 7 (06): : 696 - 700
  • [6] ANTI-INFLAMMATORY AND ANTI-PYRETIC ACTIVITIES OF BETA-SITOSTEROL
    GUPTA, MB
    NATH, R
    SRIVASTAVA, N
    SHANKER, K
    KISHOR, K
    BHARGAVA, KP
    [J]. PLANTA MEDICA, 1980, 39 (02) : 157 - 163
  • [7] ANTI-INFLAMMATORY AND ANTI-PYRETIC ACTIVITIES OF MORUS-INDICA
    CHATTERJEE, GK
    BURMAN, TK
    NAGCHAUDHURI, AK
    PAL, SP
    [J]. PLANTA MEDICA, 1983, 48 (02) : 116 - 119
  • [8] Analgesic, anti-inflammatory and anti-pyretic activities of Caesalpinia decapetala
    Parveen, Amna
    Akash, Muhammad Sajid Hamid
    Rehman, Kanwal
    Mahmood, Qaisar
    Qadir, Muhammad Imran
    [J]. BIOIMPACTS, 2014, 4 (01) : 43 - 48
  • [9] Analgesic, anti-inflammatory and anti-pyretic activities of Thymus linearis
    Qadir, Muhammad Imran
    Parveen, Amna
    Abbas, Khizar
    Ali, Muhammad
    [J]. PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2016, 29 (02) : 591 - 594