Gold-Catalyzed Cascade Cyclization and 1,3-Difunctionalization To Access Polysubstituted Furans

Gold-catalyzed cascade cyclization and 1,3-difunctionalization of 2-(1-alkyny)-2-alken-1-ones with N,O-acetals are described, leading to the discovery of novel 1,3-oxyaminomethylation and 1,3-aminomethylamination. Typically, by varying the reaction conditions especially the gold catalysts, these two distinct reaction pathways can be controlled in a selective manner. Moreover, tandem cyclization and 1,4-oxyaminomethylation have also been achieved.