Autophagy in drug-induced liver toxicity

被引：19

作者：

Chen, Si ^{[1
]}

Melchior, William B., Jr. ^{[1
]}

Wu, Yuanfeng ^{[1
]}

Guo, Lei ^{[1
]}

机构：

[1] US FDA, Div Biochem Toxicol, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA

来源：

JOURNAL OF FOOD AND DRUG ANALYSIS | 2014年 / 22卷 / 02期

关键词：

autophagy; drug-induced liver toxicity; ENDOPLASMIC-RETICULUM STRESS; USNIC-ACID; CELL-DEATH; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; HEPG2; CELLS; EFAVIRENZ; HEPATOCYTES; ACTIVATION; MECHANISMS;

D O I：

10.1016/j.jfda.2014.03.007

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Liver injury resulting from exposure to drugs and chemicals is a major health problem. Autophagy is an important factor in a wide range of diseases, such as cancer, liver disease, muscular disorder, neurodegeneration, pathogen infection, and aging, and emerging evidence indicates that autophagy makes a substantial contribution to the pathogenesis of drug- and chemical-induced liver toxicity. In this review, we summarize current knowledge on autophagy triggered by toxicants/toxins, the protective role of autophagy in liver toxicity, and the underlying molecular mechanisms. We also highlight experimental approaches for studying autophagy. Copyright (C) 2014, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC. All rights reserved.

引用

页码：161 / 168

页数：8

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