An investigation of antimicrobial usage patterns by small animal veterinarians in South Africa

Aim: At present very little information is available on antimicrobial use patterns in small animal veterinary practice in South Africa. The aim of this study was firstly to provide some indication of antimicrobial use patterns, and secondly to ascertain if the country's small animal veterinarians make use of prudent use guidelines to optimise their antimicrobial use in order to minimise the development of antimicrobial resistance. Methodology: In order to understand use patterns, a questionnaire was circulated to registered South African veterinarians, whose responses were evaluated by descriptive statistics. The prevalence of antimicrobial resistance was evaluated for dogs from samples submitted for culture and susceptibility testing for the period 2007-2013 from the only faculty of Veterinary Science in the country. The resistance data was organized into contingency tables and yearly trends in resistance evaluated by means of a chi-square. The use of antimicrobials from the survey were compared to the laboratory result to ascertain the degree of prudent use of the antimicrobials in small animal practice in a developing country. Results: The responses from the questionnaire indicated that South African veterinarians predominantly (91.16%) used antimicrobials empirically before resorting to laboratory testing and that antimicrobial compounding and off label use (86.19%) of human registered medication was common practice. A worrying finding was that a large number of clients attempted antimicrobial treatment of their pets prior to seeking veterinary assistance. In terms of monitored resistance, annual prevalence of resistance was above 10% and multiple drug resistance was above 50% for all the isolates. Conclusion: It is concluded that antimicrobial resistant bacteria are present in small companion animal practice in South Africa which requires better implementation of prudent use guidelines. (C) 2016 Elsevier B.V. All rights reserved.