A hyaluronic acid-methotrexate conjugate for targeted therapy of rheumatoid arthritis

被引：109
|
作者：
Shin, Jung Min [1 ]
Kim, Seol-Hee [2 ,3 ]
Thambi, Thavasyappan [1 ]
You, Dong Gil [1 ]
Jeon, Jueun [1 ]
Lee, Jong Oh [4 ]
Chung, Bong Youl [4 ]
Jo, Dong-Gyu [2 ,5 ]
Park, Jae Hyung [1 ,5 ]
机构：
[1] Sungkyunkwan Univ, Sch Chem Engn, Coll Engn, Suwon 440746, South Korea
[2] Sungkyunkwan Univ, Sch Pharm, Suwon 440746, South Korea
[3] Korea Res Inst Stand & Sci, Ctr Bioanal, Taejon 305340, South Korea
[4] Humedix Co Ltd, Anyang 431767, South Korea
[5] Sungkyunkwan Univ, Dept Hlth Sci & Technol, SAIHST, Suwon 440746, South Korea
来源：
CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 57期
关键词：
NANOPARTICLES; CYTOKINES; JOINT;
D O I：
10.1039/c4cc02595d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In an effort to improve the therapeutic efficacy of methotrexate (MTX), we prepared the hyaluronic acid-MTX conjugate for targeted therapy of rheumatoid arthritis (RA). Owing to the pH-sensitive nature of the conjugate, MTX was rapidly released under the mildly acidic conditions, similar to the environment of inflamed synovial tissue in RA.
引用
收藏
页码：7632 / 7635
页数：4
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