Total synthesis of (+)-conagenin

被引：11
|
作者：
Chakraborty, Tushar Kanti [1 ]
Sudhakar, Gangarajula [1 ]
机构：
[1] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India
来源：
TETRAHEDRON LETTERS | 2006年 / 47卷 / 33期
关键词：
conagenin; epoxide opening; 2-methyl-1,3-diol; immunomodulator;
D O I：
10.1016/j.tetlet.2006.06.087
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The total synthesis of the immunomodulator, (+)-conagenin was achieved using, as a key step, a method developed by us for the synthesis of 2-methyl-1,3-diols via Ti(III)-mediated diastereo- and regioselective opening of trisubstituted 2,3-epoxy alcohols, to carry out the stereoselective construction of its pentanoic acid segment. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5847 / 5849
页数：3
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