Role of Gonadotropin-Releasing Hormone (GnRH) in Ovarian Cancer

被引：23
|
作者：
Gruendker, Carsten [1 ]
Emons, Guenter [1 ]
机构：
[1] Univ Med Gottingen, Dept Gynecol & Obstet, D-37075 Gottingen, Germany
来源：
CELLS | 2021年 / 10卷 / 02期
关键词：
ovarian cancer; gonadotropin-releasing hormone; GnRH; LHRH; PHASE-II TRIAL; EPIDERMAL-GROWTH-FACTOR; N-TERMINAL KINASE; SIGNAL-TRANSDUCTION PATHWAYS; MESSENGER-RIBONUCLEIC-ACID; C-FOS EXPRESSION; RECEPTOR GENE-EXPRESSION; SERUM RESPONSE ELEMENT; PITUITARY-GONADAL AXIS; HIGH-AFFINITY BINDING;
D O I：
10.3390/cells10020437
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The hypothalamus-pituitary-gonadal (HPG) axis is the endocrine regulation system that controls the woman's cycle. The gonadotropin-releasing hormone (GnRH) plays the central role. In addition to the gonadotrophic cells of the pituitary, GnRH receptors are expressed in other reproductive organs, such as the ovary and in tumors originating from the ovary. In ovarian cancer, GnRH is involved in the regulation of proliferation and metastasis. The effects on ovarian tumors can be indirect or direct. GnRH acts indirectly via the HPG axis and directly via GnRH receptors on the surface of ovarian cancer cells. In this systematic review, we will give an overview of the role of GnRH in ovarian cancer development, progression and therapy.
引用
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页码：1 / 17
页数：17
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