Management of dyslipidaemia in patients with coronary heart disease: Results from the ESC-EORP EUROASPIRE V survey in 27 countries

被引：218

作者：

De Backer, Guy ^{[1
]}

Jankowski, Piotr ^{[2
,30
,91
]}

Kotseva, Kornelia ^{[3
,4
,46
,145
]}

Mirrakhimov, Erkin ^{[5
,38
]}

Reiner, Zeljko ^{[6
,27
,37
,57
]}

Ryden, Lars ^{[7
,30
,47
]}

Tokgozoglu, Lale ^{[8
,43
]}

Wood, David ^{[3
,4
,145
]}

De Bacquer, Dirk ^{[1
]}

Abreu, A. ^{[9
,112
]}

Aguiar, C. ^{[10
,110
]}

Badariene, J. ^{[11
]}

Bruthans, J. ^{[12
,13
]}

Castro Conde, A. ^{[14
]}

Cifkova, R. ^{[12
,13
]}

Crowley, J. ^{[15
,78
]}

Davletov, K. ^{[16
]}

De Smedt, D. ^{[1
]}

De Sutter, J. ^{[17
]}

Deckers, J. W. ^{[18
]}

Dilic, M. ^{[19
]}

Dolzhenko, M. ^{[20
]}

Druais, H. ^{[21
]}

Dzerve, V. ^{[22
,88
]}

Erglis, A. ^{[22
]}

Fras, Z. ^{[23
,120
]}

Gaita, D. ^{[24
,113
]}

Gotcheva, N. ^{[25
,55
]}

Grobbee, D. E. ^{[26
]}

Gyberg, V. ^{[27
]}

Ali, H. Hasan ^{[28
]}

Heuschmann, P. ^{[29
]}

Hoes, A. W. ^{[26
]}

Lalic, N. ^{[31
]}

Lehto, S. ^{[32
]}

Lovic, D. ^{[33
,117
]}

Maggioni, A. P. ^{[34
]}

Mancas, S. ^{[24
,113
]}

Marques-Vidal, P. ^{[35
]}

Mellbin, L. ^{[36
,47
]}

Milicic, D. ^{[37
,57
]}

Oganov, R. ^{[39
]}

Pogosova, N. ^{[39
]}

Stagmo, M. ^{[40
]}

Stoerk, S. ^{[29
,41
]}

Sundvall, J. ^{[42
]}

Tsioufis, K. ^{[44
]}

Vulic, D. ^{[45
]}

Wood, D. A. ^{[46
]}

Jennings, C. ^{[46
,145
]}

机构：

[1] Univ Ghent, Dept Publ Hlth & Primary Care, Ghent, Belgium

[2] Jagiellonian Univ, Coll Med, Inst Cardiol, Dept Cardiol, Krakow, Poland

[3] Imperial Coll London, Natl Heart & Lung Inst, Cardiovasc Med, London, England

[4] Natl Univ Ireland Galway, Natl Inst Prevent Cardiol, Galway, Ireland

[5] Kyrgyz State Med Acad, Dept Internal Med, Bishkek, Kyrgyzstan

[6] Univ Zagreb, Sch Med, Univ Hosp Ctr Zagreb, Dept Internal Med, Zagreb, Croatia

[7] Karolinska Inst, Dept Med K2, Stockholm, Sweden

[8] Hacettepe Univ, Dept Cardiol, Ankara, Turkey

[9] Hosp Santa Marta, Ctr Hosp Lisboa Cent, Lisbon, Portugal

[10] Hosp Santa Cruz Lisbon, Ctr Hosp Lisboa Ocidental, Lisbon, Portugal

[11] Vilnius Univ Hosp Santaros Klinikos, Vilnius, Lithuania

[12] Charles Univ Prague, Fac Med 1, Ctr Cardiovasc Prevent, Prague, Czech Republic

[13] Thomayer Hosp, Prague, Czech Republic

[14] Hosp Univ La Paz, Madrid, Spain

[15] Natl Inst Prevent Cardiol, West Ireland Cardiac Fdn, Galway, Ireland

[16] Kazakh Natl Med Univ, Alma Ata, Kazakhstan

[17] AZ Maria Middelares Gent, Ghent, Belgium

[18] Erasmus MC, Rotterdam, Netherlands

[19] Univ Sarajevo, Clin Ctr, Sarajevo, Bosnia & Herceg

[20] NSC MD Strazhesko Inst Cardiol MAS Ukraine, Dept Cardiol, Kiev, Ukraine

[21] European Heart House, EURObservat Res Programme Dept, Nice, France

[22] Pauls Stradind Univ Hosp, Riga, Latvia

[23] Univ Med Ctr Ljubljana, Ljubljana, Slovenia

[24] Inst Cardiovasc Med Timisoara, Timisoara, Romania

[25] Natl Heart Hosp, Sofia, Bulgaria

[26] UMC Utrecht, Div Julius Ctr, Utrecht, Netherlands

[27] Karolinska Univ Solna, Stockholm, Sweden

[28] Assiut Univ Hosp, Assiut, Egypt

[29] Univ Wurzburg, Wurzburg, Germany

[30] Jagiellonian Univ, Inst Cardiol, Coll Med, Dept Cardiol Intervent Electrocardiol & Arterial, Krakow, Poland

[31] Clin Ctr Serbia, Clin Endocrinol Diabet & Metab Dis, Dept Metab Disorder Intens Treatment & Cell Thera, Belgrade, Serbia

[32] Kuopio Univ Hosp, Dept Med, Kuopio, Finland

[33] Clin Internal Dis Intermed, Dept Cardiol, Nish, Serbia

[34] European Heart House, Nice, France

[35] Lausanne Univ Hosp, CHUV, Lausanne, Switzerland

[36] Karolinska Univ Hosp Stockholm, Dept Cardiol, Stockholm, Sweden

[37] Univ Hosp Ctr Zagreb, Zagreb, Croatia

[38] Osh Cardio Med Ctr, Osh, Kyrgyzstan

[39] Natl Res Ctr Prevent Med, Moscow, Russia

[40] Skanes Univ Sjukhus, Malmo, Sweden

[41] Univ Klin Wurzburg, Wurzburg, Germany

[42] Natl Inst Hlth & Welf, Genom & Biomarkers Unit, Biochem Lab, Helsinki, Finland

[43] Hacettepe Univ, Sch Med Hosp, Ankara, Turkey

[44] Univ Athens, Sch Med, Hippokrateio Hosp, Dept Cardiol 1, Athens, Greece

[45] Fac Med, Banja Luka, Bosnia & Herceg

[46] Imperial Coll London, Fac Med, Natl Heart & Lung Inst, Cardiovasc Med, London, England

[47] Karolinska Univ Hosp, Dept Cardiol, Stockholm, Sweden

[48] Univ Ghent, Ghent, Belgium

[49] Univ Hosp Gent, Ghent, Belgium

[50] Jessa Ziekenhuis, Hasselt, Belgium

来源：

ATHEROSCLEROSIS | 2019年 / 285卷

关键词：

LDL-Cholesterol; Coronary heart disease; EUROASPIRE; Secondary prevention; Dyslipidaemia; Lipid lowering therapy; CLINICAL-PRACTICE; MYOCARDIAL-INFARCTION; RISK-FACTORS; CARDIOVASCULAR OUTCOMES; PREVENTION GUIDELINES; EUROPEAN GUIDELINES; ESC/EAS GUIDELINES; LOWERING THERAPY; STATIN THERAPY; TASK-FORCE;

D O I：

10.1016/j.atherosclerosis.2019.03.014

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and aims: One of the objectives of the ESC-EORP EUROASPIRE V survey is to determine how well European guidelines on the management of dyslipidaemias are implemented in coronary patients. Methods: Standardized methods were used by trained technicians to collect information on 7824 patients from 130 centers in 27 countries, from the medical records and at a visit at least 6 months after hospitalization for a coronary event. All lipid measurements were performed in one central laboratory. Patients were divided into three groups: on high-intensity LDL-C-lowering-drug therapy (LLT), on low or moderate-intensity LLT and on no LLT. Results: At the time of the visit, almost half of the patients were on a high-intensity LLT. Between hospital discharge and the visit, LLT had been reduced in intensity or interrupted in 20.8% of the patients and had been started or increased in intensity in 11.7%. In those who had interrupted LLT or had reduced the intensity, intolerance to LLT and the advice of their physician were reported as the reason why in 15.8 and 36.8% of the cases, respectively. LDL-C control was better in those on a high-intensity LLT compared to those on low or moderate intensity LLT. LDL-C control was better in men than women and in patients with self-reported diabetes. Conclusions: The results of the EUROASPIRE V survey show that most coronary patients have a less than optimal management of LDL-C. More professional strategies are needed, aiming at lifestyle changes and LLT adapted to the need of the individual patient.

引用

页码：135 / 146

页数：12

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