Pharmacologically active 2-(1H-pyrazol-1-yl)acetamides

被引：6
|
作者：
Zalaru, Christina [1 ]
Dumitrascu, Florea [2 ]
Draghici, Constantin [2 ]
Cristea, Elena [3 ]
Tarcomnicu, Isabela [1 ,4 ]
机构：
[1] Univ Bucharest, Fac Chem, Dept Organ Chem Bucharest, 90-92 Rd Panduri, Bucharest, Romania
[2] Romanian Acad, Inst Organ Chem CD Nenitescu, Bucharest, Romania
[3] Univ Med & Pharmaceut Carol Davila, Clin & Sanit Chem Labs, Bucharest, Romania
[4] Pharma Serv Int, Bucharest, Romania
来源：
ARKIVOC | 2009年
关键词：
Acetamides; pyrazoles; local anesthetics; PYRAZOLES; SYDNONES;
D O I：
10.3998/ark.5550190.0010.229
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Ten title compounds were synthesized by N-alkylation of pyrazoles with 2-iodoacetanilides; they were characterized using spectroscopic methods and pharmacologically tested. Acute toxicity, local anesthetic and anti-arrhythmic activities were assessed using established protocols.
引用
收藏
页码：308 / 314
页数：7
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