Cadherin expression in ovarian carcinoma and malignant mesothelioma cell effusions

被引：21
|
作者：
Sivertsen, Stine
Berner, Aasmund
Michael, Claire W.
Bedrossian, Carlos
Davidson, Ben [1 ]
机构：
[1] Univ Oslo, Dept Pathol, Norwegian Radium Hosp, Natl Hosp, N-0310 Oslo, Norway
[2] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA
[3] Norwegian Amer Hosp, Chicago, IL USA
来源：
ACTA CYTOLOGICA | 2006年 / 50卷 / 06期
关键词：
cadherins; carcinoma; ovarian; primary peritoneal; mesothelioma;
D O I：
10.1159/000326027
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Objective To analyze potential differences in cadherin expression between ovarian carcinoma/primary peritoneal carcinoma (OC/PPC) and malignant mesothelioma (MM) at this anatomic site. Study Design MM (N = 24) and OC/PPC (N = 53) effiisions were analyzed for E-cadherin, N-cadberin and P-cadherin protein expression using immunocytochemistry. Results Both MM and OC/PPC cells showed frequent expression of all 3 cadherins. OC/PPC specimens expressed E-cadherin and N-cadherin in 52 of 53 cases and P-cadherin in 51 of 53 cases. MM effusions expressed E-cadherin, N-cadherin and P-cadherin in 22 of 24, 21 of 24 and 23 of 24 cases, respectively. The differences in the percentage of cadherin-positive cells was weakly Significant for P-cadherin (higher expression in MM, p = 0.04), but E-cadherin and N-cadherin expression was comparable (p > 0.05). Conclusion MM and OC/PPC coexpress different cadherin family members. P-cadherin, E-cadherin and N-cadherin are not useful for differentiation between OC/PPC and MM in effusions.
引用
收藏
页码：603 / 607
页数：5
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