Aripiprazole as an Adjunct to Clozapine Therapy in Adolescents with Early-onset Schizophrenia: A Retrospective Chart Review

被引:18
|
作者
Bachmann, C. J. [1 ]
Lehr, D. [2 ]
Theisen, F. M. [1 ]
Preiss, M. [1 ]
机构
[1] Univ Hosp Giessen & Marburg, Dept Child & Adolescent Psychiat, Giessen, Germany
[2] Univ Marburg, Inst Med Psychol, D-35032 Marburg, Germany
关键词
PLACEBO-CONTROLLED TRIAL; TREATMENT-RESISTANT SCHIZOPHRENIA; ATYPICAL ANTIPSYCHOTIC-DRUG; DOUBLE-BLIND; OPEN-LABEL; REFRACTORY SCHIZOPHRENIA; ROBUST PHARMACOLOGY; AUGMENTATION; RISPERIDONE; AMISULPRIDE;
D O I
10.1055/s-0029-1202266
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Introduction: Combination of antipsychotic substances is a therapeutic option increasingly applied in patients with schizophrenia, who do not respond to antipsychotic monotherapy. Recently, various reports on combination of clozapine with aripiprazole in adults have been published. As there is not yet data on adolescent patients, we aimed to study the above-mentioned augmentation strategy in this population. Methods: We included 15 patients with schizophrenia from a child and adolescent psychiatric department (8 male; mean age 19.3 [SD +/- 1.2, range 17.2-21.2] years). Patients had been under clozapine treatment, followed by aripiprazole augmentation. Retrospectively, patients' medical records were reviewed, using a rating scale in analogy to the Clinical Global Impressions (CGI) scale. Results: Mean observation time was 11.1 [SD +/- 9.7] months. Mean CGI-Severity scores improved significantly (p=0.003, d=0.76) from 5.3 (baseline) to 4.5 (endpoint; last observation carried forward (LOCF)). CGI-Improvement scores decreased from 3.7 (after I month) to 3.3 (endpoint; LOCF)(p=0.212, d=0.45). Conclusions: In adolescents with schizophrenia, aripiprazole augmentation of clozapine treatment might be an effective therapeutic strategy. Prospective studies for this age group are required to obtain more specific clinical data on clinical effectiveness.
引用
收藏
页码:153 / 157
页数:5
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