Protective axis of the renin-angiotensin system in the brain

被引:44
|
作者
Gironacci, Mariela M. [1 ]
Cerniello, Flavia M. [1 ]
Carbajosa, Nadia A. Longo [1 ]
Goldstein, Jorge [2 ]
Cerrato, Bruno D. [1 ]
机构
[1] Univ Buenos Aires, Fac Farm & Bioquim, Inst Quim Fisicoquim Biolog CONICET, Dept Quim Biolog, Buenos Aires, DF, Argentina
[2] Univ Buenos Aires, Fac Med, Inst Fisiolog Biofis Houssay CONICET UBA, Lab Neurofisiopatolog, Buenos Aires, DF, Argentina
关键词
angiotensin-(1-7); angiotensin-converting enzyme 2 (ACE2); baroreflex; hypertension; Mas receptor; noradrenergic neurotransmission; renin-angiotensin system (RAS); ROSTRAL VENTROLATERAL MEDULLA; NUCLEUS-TRACTUS-SOLITARII; SYMPATHETIC AFFERENT REFLEX; CONVERTING ENZYME 2; BLOOD-PRESSURE; BAROREFLEX FUNCTION; TRANSGENIC RATS; SELECTIVE OVEREXPRESSION; SUBFORNICAL ORGAN; OXIDATIVE STRESS;
D O I
10.1042/CS20130450
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The RAS (renin angiotensin system) is composed of two arms: the pressor arm containing Angll (angiotensin II)/ACE (angiotensin-converting enzyme)/AT(1)Rs (AngII type 1 receptors), and the depressor arm represented by Ang-(1-7) [angiotensin-(1-7)]/ACE2/Mas receptors. All of the components of the RAS are present in the brain. Within the brain, Ang-(1-7) contributes to the regulation of BP (blood pressure) by acting at regions that control cardiovascular function such that, when Ang-(1-7) is injected into the nucleus of the solitary tract, caudal ventrolateral medulla, paraventricular nucleus or anterior hypothalamic area, a reduction in BP occurs; however, when injected into the rostral ventrolateral medulla, Ang-(1-7) stimulates an increase in BP In contrast with Angll, Ang-(1-7) improves baroreflex sensitivity and has an inhibitory neuromodulatory role in hypothalamic noradrenergic neurotransmission. Ang-(1-7) not only exerts effects related to BP regulation, but also acts as a cerebroprotective component of the RAS by reducing cerebral infarct size and neuronal apoptosis. In the present review, we provide an overview of effects elicited by Ang-(1-7) in the brain, which suggest a potential role for Ang-(1-7) in controlling the central development of hypertension.
引用
收藏
页码:295 / 306
页数:12
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