Neopterin Predicts Disease Severity in Hospitalized Patients With COVID-19

被引：35
|
作者：
Bellmann-Weiler, Rosa [1 ]
Lanser, Lukas [1 ]
Burkert, Francesco [1 ]
Seiwald, Stefanie [1 ]
Fritsche, Gernot [1 ]
Wildner, Sophie [1 ]
Schroll, Andrea [1 ]
Koppelstatter, Sabine [1 ]
Kurz, Katharina [1 ]
Griesmacher, Andrea [2 ]
Weiss, Gunter [1 ]
机构：
[1] Innsbruck Med Univ, Dept Internal Med 2, Anichstr 35, A-6020 Innsbruck, Austria
[2] Univ Innsbruck Hosp, Cent Inst Med & Chem Lab Diag, Innsbruck, Austria
来源：
OPEN FORUM INFECTIOUS DISEASES | 2021年 / 8卷 / 01期
关键词：
COVID-19; disease severity; neopterin; outcome; SARS-CoV-2; IMMUNITY; MARKER;
D O I：
10.1093/ofid/ofaa521
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This study evaluates the predictive value of circulating inflammatory markers, especially neopterin, in patients with coronavirus disease 2019 (COVID-19). Within this retrospective analysis of 115 hospitalized COVID-19 patients, elevated neopterin levels upon admission were significantly associated with disease severity, risk for intensive care unit admission, need for mechanical ventilation, and death. Therefore, neopterin is a reliable predictive marker in patients with COVID-19 and may help to improve the clinical management of patients.
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页数：5
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