Mesenchymal stem cells and transplant tolerance

被引：5
|
作者：
Vanikar, Aruna V. [1 ]
Trivedi, Hargovind L. [2 ]
Kumar, Ashutosh [3 ]
Gopal, Saroj Chooramani [4 ,5 ]
Kute, Vivek B. [2 ]
机构：
[1] Dr HL Trivedi Inst Transplantat Sci ITS, Dept Pathol Lab Med Transfus Serv & Immunohematol, GR Doshi & KM Mehta Inst Kidney Dis & Res Ctr IKD, Ahmadabad 380016, Gujarat, India
[2] Dr HL Trivedi Inst Transplantat Sci ITS, Dept Nephrol & Transplantat Med, GR Doshi & KM Mehta Inst Kidney Dis & Res Ctr IKD, Ahmadabad 380016, Gujarat, India
[3] King George Med Univ Hosp, Dept Hematol, Lucknow, Uttar Pradesh, India
[4] Banaras Hindu Univ, Inst Med Sci, Dept Pediat Surg, Varanasi 221005, Uttar Pradesh, India
[5] King George Med Univ Hosp, Lucknow, Uttar Pradesh, India
来源：
NEPHROLOGY | 2014年 / 19卷 / 07期
关键词：
immune suppression; immunology; immunopathology; stem cell; transplantation; RENAL-TRANSPLANTATION; STROMAL CELLS; BONE-MARROW; LYMPHOCYTE; INDUCTION; THERAPY;
D O I：
10.1111/nep.12258
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Different strategies are being tried to induce transplant tolerance in clinical settings; however, none of them are both safe and effective. Mesenchymal stem cells have been found to be potent immunomodulators and immunosuppressants. We discuss in this review different sources of mesenchymal stem cells and the potent role of adipose tissue-derived mesenchymal stem cells in induction of transplant tolerance including when to use them and how to use them for achieving the Utopian dream of transplant tolerance.
引用
收藏
页码：369 / 374
页数：6
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