This document adopt ANSYS Workbench and analyze the problems on fluid-solid and heating-solid coupling of high-speed vehicle, calculate the effect that the seeker's dome gain the aerodynamical forces in fluid. Using FLUENT to calculate the fluid of the seeker, then using the ANSYS Mechanical(Static Structural) module in Workbench to calculate the static structural force, finally, using the Steady-State Thermal to analyse the heat transmit, and take the result to Static Structural module to calculate the heat stress.