Synthesis and characterization of biodegradable pH-sensitive hydrogels based on poly(ε-caprolactone), methacrylic acid, and poly(ethylene glycol)

被引：42
|
作者：
Wang, Ke [1 ,2 ]
Fu, Shao Zhi [1 ,2 ]
Gu, Ying Chun [1 ,2 ,3 ]
Xu, Xu [1 ,2 ]
Dong, Peng Wei [1 ,2 ]
Guo, Gang [1 ,2 ]
Zhao, Xia [1 ,2 ]
Wei, Yu Quan [1 ,2 ]
Qian, Zhi Yong [1 ,2 ]
机构：
[1] Sichuan Univ, W China Hosp, W China Med Sch, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
[2] Sichuan Univ, W China Hosp, W China Med Sch, Ctr Canc, Chengdu 610041, Sichuan, Peoples R China
[3] Sichuan Univ, Dept Text & Clothing, Chengdu 610065, Peoples R China
来源：
POLYMER DEGRADATION AND STABILITY | 2009年 / 94卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Biodegradable; pH sensitive; Degradation; Water absorption; Dynamic swelling/deswelling; POLYELECTROLYTE HYDROGELS; RESPONSIVE HYDROGELS; SWELLING BEHAVIOR; BLOCK-COPOLYMERS; IN-VITRO; DELIVERY; POLYCAPROLACTONE; DEGRADATION; INSULIN; WATER;
D O I：
10.1016/j.polymdegradstab.2008.12.013
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
In this work, a novel biodegradable pH-sensitive hydrogel based on poly(c-caprolactone) (PCL), methoxpoly(ethylene glycol) (MPEG) and methacrylic acid (MAA) was prepared by UV-initiated free radical polymerization. The resulting macromonomers and hydrogels were characterized by MR and/or H-1 NMR. Swelling behaviour and pH sensitivity of the hydrogels were studied in detail. With increase in pH of aqueous medium from 1.2 to 7.2, swelling ratio of the hydrogels increased accordingly. The hydrolytic degradation behaviour was also investigated. The prepared biodegradable pH-sensitive hydrogel based on PCL, MPEG, and MAA might have great potential application in smart drug delivery system. (c) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：730 / 737
页数：8
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