Restoring the balance between the endothelin system and the NO system in coronary artery disease

被引：0
|
作者：
Neunteufl, T [1 ]
机构：
[1] Univ Vienna, Dept Cardiol, Vienna, Austria
来源：
ATHEROSCLEROSIS: RISK FACTORS, DIAGNOSIS, AND TREATMENT | 2002年
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Endothelial dysfunction is present in the preclinical phase of vascular disease and predicts cardiovascular events in patients at risk for coronary artery disease. Activation of the endothelin system results in coronary vasoconstriction in patients with coronary artery disease. Moreover, endothelin-1 (ET-1) raises blood pressure, induces vascular and myocardial hypertrophy and acts as the natural counterpart of nitric oxide (NO), which exerts vasodilating, antithrombotic and antiproliferative effects. Endothelin-1 is enhanced and has been demonstrated to be a prognostic marker in patients with acute ischemic syndromes and myocardial infarction. Thus, restoring the balance between the endothelin system and the NO system seems to be an attractive therapeutic strategy in coronary artery disease.
引用
收藏
页码：515 / 519
页数：5
相关论文
共 50 条
  • [1] Polymorphisms of the endothelin system as risk factor for coronary artery disease
    Ciofini, E.
    Paradossi, U.
    Prontera, C.
    Andreassi, M. G.
    Biagini, A.
    Colombo, M.
    [J]. EUROPEAN HEART JOURNAL, 2005, 26 : 577 - 577
  • [2] Mutations in genes encoding for the endothelin system and risk of coronary artery disease
    Stangl, K
    Cascorbi, I
    Hoffmeyer, S
    Brinkmann, U
    Laule, M
    Meisel, C
    Stangl, V
    Dschietzig, T
    Roots, I
    Baumann, G
    [J]. EUROPEAN HEART JOURNAL, 2001, 22 : 151 - 151
  • [3] Endothelin in coronary artery disease
    Pernow, J
    [J]. SCANDINAVIAN CARDIOVASCULAR JOURNAL, 2004, 38 (05) : 257 - 258
  • [4] Endothelin and big endothelin in coronary artery disease and in the acute coronary syndromes
    Borries, M
    Heins, M
    Fischer, Y
    Stiegler, H
    Schoebel, FC
    Reinauer, H
    Strauer, BE
    Leschke, M
    [J]. ZEITSCHRIFT FUR KARDIOLOGIE, 1996, 85 (10): : 761 - 767
  • [5] In situ endothelin in coronary artery disease
    Brody, JI
    Capuzzi, DM
    Fink, GB
    [J]. ANGIOLOGY, 1996, 47 (11) : 1027 - 1032
  • [6] Restoring balance to the American Federal System
    Moyes, HA
    [J]. PUBLIC ADMINISTRATION REVIEW, 1997, 57 (01) : 91 - 91
  • [7] THE FIBRINOLYTIC SYSTEM IN CORONARY-ARTERY DISEASE
    ROCHA, E
    SAINZ, R
    PARAMO, JA
    SOLANA, JM
    FERNANDEZ, J
    CUESTA, B
    [J]. THROMBOSIS AND HAEMOSTASIS, 1989, 62 (01) : 232 - 232
  • [8] Endothelin in Coronary Artery Disease and Myocardial Infarction
    Kolettis, Theofilos M.
    Barton, Matthias
    Langleben, David
    Matsumura, Yasuo
    [J]. CARDIOLOGY IN REVIEW, 2013, 21 (05) : 249 - 256
  • [9] The role of immune system parameters in the relationship between depression and coronary artery disease
    Kop, WJ
    Gottdiener, JS
    [J]. PSYCHOSOMATIC MEDICINE, 2005, 67 : S37 - S41
  • [10] The HLA system and coronary artery disease in the Japanese population
    Rauchhaus, M
    [J]. INTERNATIONAL JOURNAL OF CARDIOLOGY, 2000, 73 (03) : 281 - 282
12345