In vitro Antiproliferative activity of Melissa officinalis L. (Lamiaceae) leaves essential oil

被引：7
|
作者：
Niksic, Haris [1 ]
Duric, Kemal [1 ]
Sijamic, Irma [1 ]
Koric, Emina [1 ]
kusturica, Jasna [2 ]
Omeragic, Elma [1 ]
Muratovic, Samija [1 ]
机构：
[1] Univ Sarajevo, Fac Pharm, Zmaja Bosne 8, Sarajevo 71000, Bosnia & Herceg
[2] Univ Sarajevo, Fac Med, Cekalusa 90, Sarajevo 71000, Bosnia & Herceg
来源：
BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS | 2019年 / 18卷 / 05期
关键词：
Melissa officinalis L; essential oil; antiproliferative agents; MOLT-4; MCF-7; NCI-H460; PLANT ESSENTIAL OILS; ANTIOXIDANT ACTIVITIES; ANTICANCER ACTIVITY; CELL-LINES; APOPTOSIS; GROWTH; GERANIOL; BIOSYNTHESIS; CONSTITUENTS; INDUCTION;
D O I：
10.35588/blacpma.19.18.5.31
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
In the present study, we investigated the antiproliferative activity of essential oil from leaves of Melissa officinalis L. grown in Southern Bosnia and Herzegovina. In vitro evaluation of antiproliferative activity of the M. officinalis essential oil was carried out on three human tumor cell lines: MCF-7, NCI-H460 and MOLT-4 by MTT assay. M. officinalis essential oil was characterized by high percentage of monoterpenes (77,5%), followed by the sesquiterpene fraction (14,5%) and aliphatic compounds (2,2%). The main constituents of the essential oil of M. officinalis are citral (47,2%), caryophyllene oxide (10,2%), citronellal (5,4%), geraniol (6,6%), geranyl acetate (4,1%) and beta-caryophyllene (3,8%). The essential oil showed significant antiproliferative activity against three cancer cell lines, MOLT-4, MCF-7, and NCI-H460 cells, with GI50 values of <5, 6 +/- 2 and 31 +/- 17 mu g/mL, respectively. The results revealed that M. officinalis L. essential oil has a potential as anticancer therapeutic agent.
引用
收藏
页码：480 / 491
页数：12
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