A pH-responsive prodrug for real-time drug release monitoring and targeted cancer therapy

被引：92
|
作者：
Li, Shi-Ying
Liu, Li-Han
Jia, Hui-Zhen
Qiu, Wen-Xiu
Rong, Lei
Cheng, Hong
Zhang, Xian-Zheng [1 ]
机构：
[1] Wuhan Univ, Key Lab Biomed Polymers, Minist Educ, Wuhan 430072, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 80期
基金：
中国国家自然科学基金;
关键词：
APPENDED NAPHTHALIMIDE; INTRAMOLECULAR DIMERS; RATIONAL DESIGN; DELIVERY; DOXORUBICIN; STRATEGY; NANOPARTICLES; PROBES;
D O I：
10.1039/c4cc05008h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel cancer targeting and pH-responsive prodrug was successfully designed and synthesized. This M-prodrug was demonstrated to have real-time drug release monitoring capability based on the concept of contact-mediated quenching between doxorubicin and a coumarin derivative.
引用
收藏
页码：11852 / 11855
页数：4
相关论文
共 50 条
  • [1] Self-Indicating Polymer Prodrug Nanoparticles for pH-Responsive Drug Delivery in Cancer Cells and Real-Time Monitoring of Drug Release
    Kayal, Shibayan
    Kola, Prithwish
    Pal, Juthi
    Mandal, Mahitosh
    Dhara, Dibakar
    [J]. ACS APPLIED BIO MATERIALS, 2024, 7 (09): : 5810 - 5822
  • [2] pH-Responsive Nanoscale Coordination Polymer for Efficient Drug Delivery and Real-Time Release Monitoring
    Han, Kai
    Zhang, Wei-Yun
    Zhang, Jin
    Ma, Zhao-Yu
    Han, He-You
    [J]. ADVANCED HEALTHCARE MATERIALS, 2017, 6 (19)
  • [3] pH-responsive drug release and real-time fluorescence detection of porous silica nanoparticles
    Zhang, Xu
    Wang, Yamin
    Zhao, Yanbao
    Sun, Lei
    [J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2017, 77 : 19 - 26
  • [4] pH-responsive intramolecular FRET-based self-tracking polymer prodrug nanoparticles for real-time tumor intracellular drug release monitoring and imaging
    Dong, Yuman
    Du, Pengcheng
    Liu, Peng
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2020, 588
  • [5] Real-time drug release monitoring from pH-responsive CuS-encapsulated metal-organic frameworks
    Liu, Bei
    Sun, Lirong
    Lu, Xijian
    Yang, Yuping
    Peng, Hongshang
    Sun, Zhaogang
    Xu, Juan
    Chu, Hongqian
    [J]. RSC ADVANCES, 2022, 12 (18) : 11119 - 11127
  • [6] Real-time monitoring of pH-responsive drug release using a metal-phenolic network-functionalized upconversion nanoconstruct
    Hu, Feng
    Liu, Bei
    Chu, Hongqian
    Liu, Chang
    Li, Zhaohui
    Chen, Daquan
    Li, Lele
    [J]. NANOSCALE, 2019, 11 (18) : 9201 - 9206
  • [7] A pH-Responsive Zwitterionic Polyurethane Prodrug as Drug Delivery System for Enhanced Cancer Therapy
    He, Qian
    Yan, Rui
    Hou, Wanting
    Wang, Haibo
    Tian, Yali
    [J]. MOLECULES, 2021, 26 (17):
  • [8] Bioinspired phospholipid polymer prodrug as a pH-responsive drug delivery system for cancer therapy
    Wang, Haibo
    Xu, Fangming
    Li, Dandan
    Liu, Xiangsheng
    Jin, Qiao
    Ji, Jian
    [J]. POLYMER CHEMISTRY, 2013, 4 (06) : 2004 - 2010
  • [9] Conjugated Polymer Nanoparticles Based on Copper Coordination for Real-Time Monitoring of pH-Responsive Drug Delivery
    Li, Jiatong
    Du, Nan
    Tan, Ying
    Hsu, Hsien-Yi
    Tan, Chunyan
    Jiang, Yuyang
    [J]. ACS APPLIED BIO MATERIALS, 2021, 4 (03): : 2583 - 2590
  • [10] Glutathione- and pH-responsive nonporous silica prodrug nanoparticles for controlled release and cancer therapy
    Xu, Zhigang
    Liu, Shiying
    Kang, Yuejun
    Wang, Mingfeng
    [J]. NANOSCALE, 2015, 7 (13) : 5859 - 5868
12345