A genome-wide scan for a simulated data set using two newly developed methods

被引：0

作者：

Hsu, L ^{[1
]}

Aragaki, C ^{[1
]}

Quiaoit, F ^{[1
]}

Wang, XJ ^{[1
]}

Xu, XB ^{[1
]}

Zhao, LP ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA

来源：

GENETIC EPIDEMIOLOGY | 1999年 / 17卷

关键词：

combined linkage/linkage disequilibrium; conditional likelihood; linkage; linkage disequilibrium; nonparametric; semiparametric;

D O I：

暂无

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A genome-wide scan of a simulated data set for fictitious disease genes was conducted using both semiparametric and nonparametric methods. The semiparametric model-based method, which tests for linkage/linkage disequilibrium separately and together, correctly identified all three underlying disease loci along with two false positives through the linkage analysis. However, the nonparametric model-free method which tests combined linkage/linkage disequilibrium, failed to yield any results due to the lack of linkage disequilibrium information in the data. ((C)) 1999 Wiley-Liss, Inc.

引用

页码：S621 / S626

页数：6

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