Synthesis and photodynamic effects of new porphyrin/4-oxoquinoline derivatives in the inactivation of S. aureus

被引：14

作者：

Sagrillo, Fernanda Savacini ^{[1
,2
,3
,4
,5
,6
]}

Dias, Cristina ^{[4
]}

Gomes, Ana T. P. C. ^{[5
,6
]}

Faustino, Maria A. F. ^{[1
,2
,3
]}

Almeida, Adelaide ^{[5
,6
]}

de Souza, Alan Goncalves ^{[4
]}

Pinto Costa, Amanda Rodrigues ^{[4
]}

Santos Boechat, Fernanda da Costa ^{[4
]}

Bastos Vieira de Souza, Maria Cecilia ^{[4
]}

Neves, Maria G. P. M. S. ^{[1
,2
,3
]}

Cavaleiro, Jose A. S. ^{[1
,2
,3
]}

机构：

[1] Univ Aveiro, QOPNA, P-3810193 Aveiro, Portugal

[2] Univ Aveiro, LAQV REQUIMTE, P-3810193 Aveiro, Portugal

[3] Univ Aveiro, Dept Chem, P-3810193 Aveiro, Portugal

[4] Univ Fed Fluminense, Inst Quim, Programa Posgrad Quim, BR-24010141 Rio De Janeiro, Brazil

[5] Univ Aveiro, Dept Biol, Aveiro, Portugal

[6] Univ Aveiro, CESAM, Aveiro, Portugal

来源：

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES | 2019年 / 18卷 / 08期

关键词：

RESISTANT STAPHYLOCOCCUS-AUREUS; IN-VITRO; GLYCOPORPHYRIN DERIVATIVES; ESCHERICHIA-COLI; THERAPY; PORPHYRINS; BACTERIAL; PHOTOINACTIVATION; INFECTIONS; VIRUS;

D O I：

10.1039/c9pp00102f

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New porphyrin/4-oxoquinoline conjugates were synthesized from the Heck coupling reaction of a beta-brominated porphyrin with 1-allyl-4-oxoquinoline derivatives, followed by demetallation and deprotection affording the promising photosensitizers 9a-e. Singlet oxygen studies have demonstrated that all the porphyrin/4-oxoquinoline conjugates 9a-e were capable of producing cytotoxic species and found to be excellent photosensitizing agents in the inactivation of S. aureus by the antimicrobial photodynamic therapy (aPDT) protocol.

引用

页码：1910 / 1922

页数：13

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