Phase diagrams and thermodynamic properties of binary systems of drugs

被引:40
|
作者
Sangster, J [1 ]
机构
[1] Sangster Res Labs, Montreal, PQ H3G 2A4, Canada
关键词
phase diagrams; thermodynamic properties;
D O I
10.1063/1.556040
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The phase diagram data of 60 binary systems of drugs were evaluated with the aid of a computer-coupled phase diagram/thermodynamic analysis. Data for this analysis were obtained by an exhaustive literature search (110 reference). Among the results of this analysis are the excess Gibbs energy of liquid and solid solution phases, and the thermodynamic properties of intermediate compounds. For each system a phase diagram was calculated; such calculated diagrams are thermodynamically consistent and are offered as the best constructions which carl be deduced from available data. (C) 1999 American Institute of Physics and American Chemical Society. [S0047-2689(99)00303-7].
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页码:889 / 930
页数:42
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