Requirement of cofactors for RXR/RAR-mediated transcriptional activation in vitro

被引：5
|
作者：
Valcarcel, R
Meyer, M
Meisterernst, M
Stunnenberg, HG
机构：
[1] EUROPEAN MOL BIOL LAB,GENE EXPRESS PROGRAMME,D-69117 HEIDELBERG,GERMANY
[2] UNIV MUNICH,MOL BIOL LAB,GENZENTRUM,D-81375 MUNICH,GERMANY
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1997年 / 1350卷 / 03期
关键词：
heterodimer RXR/RAR; cofactor; transcription; RAR beta 2 promoter;
D O I：
10.1016/S0167-4781(96)00234-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Using crude in vitro systems, we have previously shown that RXR/RAR heterodimers are able to activate transcription from the RAR beta 2 promoter in a retinoid-dependent manner. Here we demonstrate that cofactors distinct from general transcription factors or receptors are required to mediate retinoic acid-dependent transcription in vitro.
引用
收藏
页码：229 / 234
页数：6
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