Cortical atrophy patterns of incident MCI subtypes in the Mayo Clinic Study of Aging

被引：17

作者：

Machulda, Mary M. ^{[1
]}

Lundt, Emily S. ^{[2
]}

Albertson, Sabrina M. ^{[2
]}

Spychalla, Anthony J. ^{[3
]}

Schwarz, Christopher G. ^{[3
]}

Mielke, Michelle M. ^{[4
,5
]}

Jack, Clifford R., Jr. ^{[3
]}

Kremers, Walter K. ^{[2
]}

Vemuri, Prashanthi ^{[3
]}

Knopman, David S. ^{[5
]}

Jones, David T. ^{[5
]}

Bondi, Mark W. ^{[6
,7
]}

Petersen, Ronald C. ^{[5
]}

机构：

[1] Mayo Clin, Dept Psychiat & Psychol, Div Neurocognit Disorders, Rochester, MN USA

[2] Mayo Clin, Div Biomed Stat & Informat, Dept Hlth Sci Res, Rochester, MN USA

[3] Mayo Clin, Dept Radiol, Rochester, MN USA

[4] Mayo Clin, Div Epidemiol, Dept Hlth Sci Res, Rochester, MN USA

[5] Mayo Clin, Dept Neurol, Rochester, MN USA

[6] Univ Calif San Diego, Sch Med, Dept Psychiat, 9500 Gillman Dr, La Jolla, CA 92093 USA

[7] Vet Affairs San Diego Healthcare Syst, San Diego, CA USA

来源：

ALZHEIMERS & DEMENTIA | 2020年 / 16卷 / 07期

基金：

美国国家卫生研究院;

关键词：

cluster analysis; cortical thickness; mild cognitive impairment; neuropsychology; MILD COGNITIVE IMPAIRMENT; GREY-MATTER; DEMENTIA; THICKNESS; PROGRESSION; REVERSION; VOLUME; NORMS;

D O I：

10.1002/alz.12108

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: We examined differences in cortical thickness in empirically derived mild cognitive impairment (MCI) subtypes in the Mayo Clinic Study of Aging. Methods: We compared cortical thickness of four incident MCI subtypes (n = 192) to 1257 cognitive unimpaired individuals. Results: The subtle cognitive impairment cluster had atrophy in the entorhinal and parahippocampal cortex. The amnestic, dysnomic, and dysexecutive clusters also demonstrated entorhinal cortex atrophy as well as thinning in temporal, parietal, and frontal isocortex in somewhat different patterns. Discussion: We found patterns of atrophy in each of the incident MCI clusters that corresponded to their patterns of cognitive impairment. The identification of MCI subtypes based on cognitive and structural features may allow for more efficient trial and study designs. Given individuals in the subtle cognitive impairment cluster have less structural changes and cognitive decline and may represent the earliest group, this could be a unique group to target with early interventions.

引用

页码：1013 / 1022

页数：10

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