Comparison of in vitro chondrogenic potential of human mesenchymal stem cells derived from bone marrow and adipose tissue

被引：43
|
作者：
Danisovic, L'ubos [1 ]
Varga, Ivan [2 ,3 ]
Polak, Stefan [2 ]
Ulicna, Marcela [1 ]
Hlavackova, Livia [4 ]
Bohmer, Daniel [1 ]
Vojtassak, Jan [1 ]
机构：
[1] Comenius Univ, Fac Med, Inst Med Biol & Genet, Bratislava 81108, Slovakia
[2] Comenius Univ, Fac Med, Inst Histol & Embryol, Bratislava 81108, Slovakia
[3] Slovak Med Univ, Fac Med Special Studies, Inst Histol & Embryol, Bratislava 83303, Slovakia
[4] Comenius Univ, Fac Med, Inst Pathol, Bratislava 81108, Slovakia
来源：
GENERAL PHYSIOLOGY AND BIOPHYSICS | 2009年 / 28卷 / 01期
关键词：
Chondrogenic potential; Mesenchymal stem cells; Bone marrow; Adipose tissue; In vitro study; STROMAL CELLS; ARTICULAR-CARTILAGE; GENE-EXPRESSION; IMMUNOLOGICAL-PROPERTIES; CLINICAL-APPLICATIONS; DIFFERENTIATION; DEFECTS; CULTURE; CHONDROCYTES;
D O I：
10.4149/gpb_2009_01_56
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In the present work, the human bone marrow and adipose tissue-derived mesenchymal stem cells (MSCs) were isolated and expanded under in vitro condition. After their phenotypic analysis, the chondrogenic differentiation was induced by using of the three-dimensional culture system without supplementation of growth factors, and their chondrogenic potential was compared. Obtained results proved that both types of MSCs undergo the process of chondrogenic differentiation. Comparative analysis showed that chondrogenic potential of adipose tissue-derived MSCs was slightly decreased in comparison with bone marrow-derived MSCs. However, both evaluated MSCs may play important role in the cartilage tissue engineering.
引用
收藏
页码：56 / 62
页数：7
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