APOE Genotype Effects on Intrinsic Brain Network Connectivity in Patients with Amnestic Mild Cognitive Impairment

被引:16
|
作者
Wang, Zan [1 ]
Dai, Zhengjia [2 ,3 ,4 ]
Shu, Hao [1 ]
Liao, Xuhong
Yue, Chunxian [1 ]
Liu, Duan [1 ]
Guo, Qihao [5 ]
He, Yong [3 ,4 ]
Zhang, Zhijun [1 ]
机构
[1] Southeast Univ, Affiliated ZhongDa Hosp, Sch Med, Dept Neurol, Nanjing 210009, Jiangsu, Peoples R China
[2] Sun Yat Sen Univ, Dept Psychol, Guangzhou 510006, Guangdong, Peoples R China
[3] Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
[4] Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing 100875, Peoples R China
[5] Fudan Univ, Huashan Hosp, Dept Neurol, Shanghai 200040, Peoples R China
来源
SCIENTIFIC REPORTS | 2017年 / 7卷
基金
北京市自然科学基金; 中国国家自然科学基金; 国家自然科学基金国际合作与交流项目;
关键词
STATE FUNCTIONAL CONNECTIVITY; APOLIPOPROTEIN-E EPSILON-4; ALZHEIMERS-DISEASE; RETROSPLENIAL CORTEX; MEMORY DECLINE; WORKING-MEMORY; PATTERNS; DEMENTIA; PREDICTION; MCI;
D O I
10.1038/s41598-017-00432-0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Whether and how the apolipoprotein E (APOE) epsilon 4 genotype specifically modulates brain network connectivity in patients with amnestic mild cognitive impairment (aMCI) remain largely unknown. Here, we employed resting-state ('task-free') functional MRI and network centrality approaches to investigate local (degree centrality, DC) and global ( eigenvector centrality, EC) functional integrity in the whole-brain connectome in 156 older adults, including 66 aMCI patients (27 epsilon 4-carriers and 39 non-carriers) and 90 healthy controls (45 epsilon 4-carriers and 45 non-carriers). We observed diagnosis-by-genotype interactions on DC in the left superior/middle frontal gyrus, right middle temporal gyrus and cerebellum, with higher values in the epsilon 4-carriers than non-carriers in the aMCI group. We further observed diagnosis- by-genotype interactions on EC, with higher values in the right middle temporal gyrus but lower values in the medial parts of default-mode network in the epsilon 4-carriers than non-carriers in the aMCI group. Notably, these genotype differences in DC or EC were absent in the control group. Finally, the network connectivity DC values were negatively correlated with cognitive performance in the aMCI epsilon 4-carriers. Our findings suggest that the APOE genotype selectively modulates the functional integration of brain networks in patients with aMCI, thus providing important insight into the gene-connectome interaction in this disease.
引用
收藏
页数:13
相关论文
共 50 条
  • [1] APOE Genotype Effects on Intrinsic Brain Network Connectivity in Patients with Amnestic Mild Cognitive Impairment
    Zan Wang
    Zhengjia Dai
    Hao Shu
    Xuhong Liao
    Chunxian Yue
    Duan Liu
    Qihao Guo
    Yong He
    Zhijun Zhang
    [J]. Scientific Reports, 7
  • [2] Apathy and Intrinsic Connectivity Networks in the Amnestic Mild Cognitive Impairment
    Lee, Chang Uk
    Joo, Soo Hyun
    Lim, Hyun Kook
    [J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2016, 19 : 256 - 256
  • [3] Apathy and intrinsic functional connectivity networks in amnestic mild cognitive impairment
    Joo, Soo Hyun
    Lee, Chang Uk
    Lim, Hyun Kook
    [J]. NEUROPSYCHIATRIC DISEASE AND TREATMENT, 2017, 13 : 61 - 67
  • [4] Altered intrinsic default mode network functional connectivity in patients with remitted geriatric depression and amnestic mild cognitive impairment
    Guan, Chengbin
    Amdanee, Nousayhah
    Liao, Wenxiang
    Zhou, Chao
    Wu, Xin
    Zhang, Xiangrong
    Zhang, Caiyi
    [J]. INTERNATIONAL PSYCHOGERIATRICS, 2022, 34 (08) : 703 - 714
  • [5] Gut microbiota interacts with intrinsic brain activity of patients with amnestic mild cognitive impairment
    Liu, Ping
    Jia, Xi-Ze
    Chen, Yi
    Yu, Yang
    Zhang, Kan
    Lin, Ya-Jie
    Wang, Bao-Hong
    Peng, Guo-Ping
    [J]. CNS NEUROSCIENCE & THERAPEUTICS, 2021, 27 (02) : 163 - 173
  • [6] Alterations of brain local functional connectivity in amnestic mild cognitive impairment
    Dan Zheng
    Wei Xia
    Zhong Quan Yi
    Pan Wen Zhao
    Jian Guo Zhong
    Hai Cun Shi
    Hua Liang Li
    Zhen Yu Dai
    Ping Lei Pan
    [J]. Translational Neurodegeneration, 7
  • [7] Alterations of brain local functional connectivity in amnestic mild cognitive impairment
    Zhen, Dan
    Xia, Wei
    Yi, Zhong Quan
    Zhao, Pan Wen
    Zhong, Jian Guo
    Shi, Hai Cun
    Li, Hua Liang
    Dai, Zhen Yu
    Pan, Ping Lei
    [J]. TRANSLATIONAL NEURODEGENERATION, 2018, 7
  • [8] Spatial Navigation and APOE in Amnestic Mild Cognitive Impairment
    Laczo, Jan
    Andel, Ross
    Vlcek, Kamil
    Matoska, Vaclav
    Vyhnalek, Martin
    Tolar, Martin
    Bojar, Martin
    Hort, Jakub
    [J]. NEURODEGENERATIVE DISEASES, 2011, 8 (04) : 169 - 177
  • [9] Effects of ApoE genotype and mild cognitive impairment on implicit learning
    Negash, Selam
    Petersen, Lindsay E.
    Geda, Yonas E.
    Knopman, David S.
    Boeve, Bradley E.
    Smith, Glenn E.
    Ivnik, Robert J.
    Howard, Darlene V.
    Howard, James H., Jr.
    Petersen, Ronald C.
    [J]. NEUROBIOLOGY OF AGING, 2007, 28 (06) : 885 - 893
  • [10] Correction to: Alterations of brain local functional connectivity in amnestic mild cognitive impairment
    Dan Zheng
    Wei Xia
    Zhong Quan Yi
    Pan Wen Zhao
    Jian Guo Zhong
    Hai Cun Shi
    Hua Liang Li
    Zhen Yu Dai
    Ping Lei Pan
    [J]. Translational Neurodegeneration, 7