DNA damage response induces structural alterations in histone H3-H4

被引：9
|
作者：
Izumi, Yudai [1 ]
Fujii, Kentaro [2 ]
Yamamoto, Satoshi [3 ]
Matsuo, Koichi [1 ]
Namatame, Hirofumi [1 ]
Taniguchi, Masaki [1 ]
Yokoya, Akinari [2 ,3 ]
机构：
[1] Hiroshima Univ, Hiroshima Synchrotron Radiat Ctr, 2-313 Kagamiyama, Hiroshima 7390046, Japan
[2] Natl Inst Quantum & Radiol Sci & Technol QST, 2-4 Ooaza Shirakata, Naka, Ibaraki 3191106, Japan
[3] Ibaraki Univ, Grad Sch Sci & Engn, 2-1-1 Bunkyo, Mito, Ibaraki 3100056, Japan
来源：
JOURNAL OF RADIATION RESEARCH | 2017年 / 58卷 / 01期
关键词：
chromatin remodeling; post-translational modification; DNA repair; histone dynamics; synchrotron radiation; circular dichroism; CIRCULAR-DICHROISM SPECTROSCOPY; SECONDARY-STRUCTURE; BETA-STRAND; PROTEINS; REPAIR; CHROMATIN; ACETYLATION; NUCLEOSOME; SPECTRA; BREAKS;
D O I：
10.1093/jrr/rrw086
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Synchrotron-radiation circular-dichroism spectroscopy was used to reveal that the DNA damage response induces a decrement of alpha-helix and an increment of beta-strand contents of histone H3-H4 extracted from X-ray-irradiated human HeLa cells. The trend of the structural alteration was qualitatively opposite to that of our previously reported results for histone H2A-H2B. These results strongly suggest that histones share roles in DNA damage responses, particularly in DNA repair processes and chromatin remodeling, via a specific structural alteration of each histone.
引用
收藏
页码：59 / 65
页数：7
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