Synthesis of ABO Histo-Blood Group Type V and VI Antigens

被引:20
|
作者
Meloncelli, Peter J. [1 ,2 ]
Lowary, Todd L. [1 ,2 ]
机构
[1] Univ Alberta, Dept Chem, Edmonton, AB T6G 2G2, Canada
[2] Univ Alberta, Alberta Ingenu Ctr Carbohydrate Sci, Gunning Lemieux Chem Ctr, Edmonton, AB T6G 2G2, Canada
基金
加拿大健康研究院; 加拿大自然科学与工程研究理事会;
关键词
GROUP-A; LEA SUBSTANCES; HELIX-POMATIA; TRISACCHARIDE; OLIGOSACCHARIDES; GLYCOSIDES; SERINE; GLYCOSYLTRANSFERASES; TETRASACCHARIDE; DISACCHARIDE;
D O I
10.1071/CH09058
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The ABO histo-blood group antigens have long been of interest to chemists, biochemists, and evolutionary biologists. However, to date, a complete synthesis of all ABO histo-blood group antigens has not been conducted, despite the potential for such a panel to provide a more detailed understanding of the biological roles of these glycan motifs. Here we report the chemical synthesis of the A, B, and H type V and VI antigens in multi-milligramme quantities as part of an overall goal to prepare all 18 A, B, and H antigens. The A and B type V and VI antigens were prepared with a 7-octen-1-yl linker, to enable future conjugation to a protein or solid support. The H type V and VI antigens were prepared as the octyl glycoside, to facilitate detailed enzyme kinetics studies.
引用
收藏
页码:558 / 574
页数:17
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