TGF-β1 regulation of dendritic cells

被引:183
|
作者
Strobl, H [1 ]
Knapp, W [1 ]
机构
[1] Univ Vienna, Inst Immunol, A-1090 Vienna, Austria
关键词
TGF-beta; dendritic cell; Langerhans cell; differentiation; antigen presentation;
D O I
10.1016/S1286-4579(99)00256-7
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Dendritic cells (DCs) represent antigen-presenting cell (APC) populations in lymphoid and nonlymphoid organs which are considered to play key roles in the initiation of antigen-specific T-cell proliferation. According to current knowledge, the net outcome of T-cell immune responses seems to be significantly influenced by the activation stage of antigen-presenting DCs. Several studies have shown that transforming growth factor-beta 1 (TGF-beta 1) inhibits in vitro activation and maturation of DCs. TGF-beta 1 inhibits upregulation of critical T-cell costimulatory molecules on the surface of DCs and reduces the antigen-presenting capacity of DCs. Thus, in addition to direct inhibitory effects of TGF-beta 1 on effector T lymphocytes, inhibitory effects of TGF-beta 1 at the level of APCs may critically contribute to previously characterized immunosuppressive effects of TGF-beta 1. In contrast to these negative regulatory effects of TGF-beta 1 on function and maturation of lymphoid tissue type DCs, certain subpopulations of immature DCs in nonlymphoid tissues are positively regulated by TGF-beta 1 signaling. In particular, epithelial-associated DC populations seem to critically require TGF-beta 1 stimulation for development and function, Recent studies established that TGF-beta 1 stimulation is absolutely required for the development of epithelial Langerhans cells (LCs) in vitro and in vivo. Furthermore, TGF-beta 1 seems to enhance antigen processing and costimulatory functions of epithelial LCs. (C) 1999 Editions scientifiques et medicales Elsevier SAS.
引用
收藏
页码:1283 / 1290
页数:8
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