Methodology of a Large Multicenter Observational Study of Patients with COVID-19 in Spanish Intensive Care Units

被引：11

作者：

Torres, Antoni ^{[1
,2
]}

Motos, Anna ^{[1
,2
]}

Ceccato, Adrian ^{[1
,2
]}

Bermejo-Martin, Jesus ^{[1
,3
,4
]}

de Gonzalo-Calvo, David ^{[1
,8
]}

Perez, Raquel ^{[6
]}

Barroso, Marta ^{[6
]}

Zubizarreta Pascual, Ion ^{[60
]}

Gonzalez, Jessica ^{[1
,2
,3
,4
,5
,6
,7
,8
]}

Fernandez-Barat, Laia ^{[1
,2
]}

Ferrer, Ricard ^{[5
]}

Riera, Jordi ^{[5
]}

Garcia-Gasulla, Dario ^{[6
]}

Penuelas, Oscar ^{[1
,7
]}

Angel Lorente, Jose ^{[1
,7
]}

Almansa, Raquel ^{[3
]}

Menendez, Rosario ^{[9
]}

Kiarostami, Kasra ^{[2
]}

Canseco, Joan ^{[1
,2
]}

Amaya Villar, Rosario ^{[10
]}

Anon, Jose M. ^{[1
,11
]}

Balan Marino, Ana ^{[12
]}

Barbera, Carme ^{[13
]}

Barberan, Jose ^{[14
]}

Blandino Ortiz, Aaron ^{[15
]}

Victoria Boado, Maria ^{[59
]}

Bustamante-Munguira, Elena ^{[16
]}

Caballero, Jesus ^{[17
]}

Luisa Canton-Bulnes, Maria ^{[18
]}

Carbajales Perez, Cristina ^{[19
]}

Carbonell, Nieves ^{[20
]}

Catalan-Gonzalez, Mercedes ^{[21
]}

de Frutos, Raul ^{[22
]}

Franco, Nieves ^{[23
]}

Galban, Cristobal ^{[24
]}

Gumucio-Sanguino, Victor D. ^{[25
]}

Del Carmen de la Torre, Maria ^{[26
]}

Diaz, Emili ^{[27
]}

Estella, Angel ^{[28
]}

Gallego, Elena ^{[29
]}

Garcia Garmendia, Jose Luis ^{[30
]}

Gomez, Jose M. ^{[31
]}

Huerta, Arturo ^{[32
]}

Jorge Garcia, Ruth Noemi ^{[33
]}

Loza-Vazquez, Ana ^{[34
]}

Marin-Corral, Judith ^{[35
]}

Martin Delgado, Maria Cruz ^{[36
]}

Martinez de la Gandara, Amalia ^{[37
]}

Martinez Varela, Ignacio ^{[38
]}

Lopez Messa, Juan ^{[39
]}

机构：

[1] CIBER Enfermedades Resp CIBERES, Madrid, Spain

[2] Univ Barcelona, Hosp Clin Barcelona, August Pi i Sunyer Biomed Res Inst IDIBAPS, Dept Pneumol, Barcelona, Spain

[3] Inst Invest Biomed Salamanca IBSAL, Grp Biomed Res Sepsis BioSepsis, Salamanca, Spain

[4] Hosp Univ Rio Hortega Valladolid, Valladolid, Spain

[5] Hosp Univ Vall dHebron, Vall dHebron Inst Recerca, Intens Care Dept, Barcelona, Spain

[6] Barcelona Supercomp Ctr BSC, Barcelona, Spain

[7] Univ Europea, Hosp Univ Getafe, Madrid, Spain

[8] Hosp Univ Arnau de Vilanova & Santa Maria, Resp Dept, IRBLleida, Lleida, Spain

[9] Univ & Polytech Hosp La Fe, Pulm Dept, Valencia, Spain

[10] Hosp Univ Virgen de Rocio, Intens Care Clin Unit, Seville, Spain

[11] Hosp Univ La Paz, Serv Med Intens, IdiPAZ, Madrid, Spain

[12] Hosp Univ San Agustin, Aviles, Asturias, Spain

[13] Hosp Santa Maria, IRBLleida, Lleida, Spain

[14] Univ San Pablo CEU, Hosp Univ HM Monteprincipe, Madrid, Spain

[15] Hosp Univ Ramon y Cajal, Serv Med Intens, Madrid, Spain

[16] Hosp Clin Univ Valladolid, Dept Intens Care Med, Valladolid, Spain

[17] Hosp Arnau Vilanova, Crit Care Dept, IRBLleida, Lleida, Spain

[18] Hosp Univ Virgen Macarena, Intens Care Clin Unit, Seville, Spain

[19] Hosp Alvaro Cunqueiro, Intens Care Unit, Vigo, Pontevedra, Spain

[20] Hosp Clin & Univ Valencia, Intens Care Unit, Valencia, Spain

[21] Hosp Univ 12 Octubre, Dept Intens Care Med, Madrid, Spain

[22] Hosp Univ Basurto, Serv Anestesiol & Reanimac, Bilbao, Vizcaya, Spain

[23] Hosp Univ Mostoles, Madrid, Spain

[24] Complejo Hosp Univ Santiago, Dept Med, CHUS, Santiago De Compostela, A Coruna, Spain

[25] Hosp Univ Bellvitge, Bellvitge Biomed Res Inst IDIBELL, Dept Intens Care, Barcelona, Spain

[26] Hosp Mataro, Barcelona, Spain

[27] Univ Autonoma Barcelona UAB, Crit Care Dept, Dept Med, Corp Sanitaria Parc Tauli, Barcelona, Spain

[28] Univ Cadiz, Hosp Univ Jerez, Fac Med, Dept Med, Cadiz, Spain

[29] Hosp Univ San Pedro Alcantara, Unidad Cuidados Intens, Caceres, Spain

[30] Hosp San Juan Dios del Aljarafe, Intens Care Unit, Seville, Spain

[31] Hosp Gen Univ Gregorio Maranon, Madrid, Spain

[32] Clin Sagrada Familia, Pulm & Crit Care Div, Emergency Dept, Barcelona, Spain

[33] Hosp Nuestra Senora de Gracia, Intens Care Dept, Zaragoza, Spain

[34] Hosp Univ Virgen de Valme, Unidad Med Intens, Seville, Spain

[35] Hosp del Mar IMIM, Crit Care Dept, Barcelona, Spain

[36] Univ Francisco de Vitoria, Hosp Univ Torrejon, Madrid, Spain

[37] Hosp Univ Infanta Leonor, Dept Intens Med, Madrid, Spain

[38] Hosp Univ Lucus Augusti, Crit Care Dept, Lugo, Spain

[39] Complejo Asistencial Univ Palencia, Palencia, Spain

[40] Univ Oviedo, Inst Univ Oncol Principado Asturias, Dept Biol Func,Hosp Cent Asturias, Inst Invest Sanitaria Principado Asturias, Oviedo, Asturias, Spain

[41] Hosp Univ Segovia, Segovia, Spain

[42] Hosp Univ Son Espases, Serv Med Intens, Palma De Mallorca, Illes Balears, Spain

[43] Hosp Univ Marques de Valdecilla, Serv Med Intens, Santander, Cantabria, Spain

[44] Univ Alcala, Dept Biomed & Biotecnol, Hosp Univ Principe Asturias, Serv Microbiol Clin, Madrid, Spain

[45] Hosp Univ Reina Sofia, Inst Maimonides IMIBIC, UGC Med Intens, Cordoba, Spain

[46] Hosp Univ Germans Trias, Serv Med Intens, Barcelona, Spain

[47] Hosp Univ Salamanca, Salamanca, Spain

[48] Hosp St Joan dAlacant, Alacant, Spain

[49] Hosp Univ & Politecn La Fe, Serv Med Intens, Valencia, Spain

[50] Hosp Verge de la Cinta, Pneumol Dept, Tarragona, Spain

来源：

ARCHIVOS DE BRONCONEUMOLOGIA | 2022年 / 58卷

关键词：

COVID-19; ICU; Observational studies; Follow-up; Biomarkers; Data management; HEALTH SURVEY; RELIABILITY; ICU;

D O I：

10.1016/j.arbres.2022.03.010

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Introduction: The COVID-19 pandemic created tremendous challenges for health-care systems. Intensive care units (ICU) were hit with a large volume of patients requiring ICU admission, mechanical ventilation, and other organ support with very high mortality. The Centro de Investigacion Biomedica en Red-Enfermedades Respiratorias (CIBERES), a network of Spanish researchers to investigate in respiratory disease, commissioned the current proposal in response to the Instituto de Salud Carlos III (ISCIII) call. Methods: CIBERESUCICOVID is a multicenter, observational, prospective/retrospective cohort study of patients with COVID-19 admitted to Spanish ICUs. Several work packages were created, including study population and ICU data collection, follow-up, biomarkers and miRNAs, data management and quality. Results: This study included 6102 consecutive patients admitted to 55 ICUs homogeneously distributed throughout Spain and the collection of blood samples from more than 1000 patients. We enrolled a large population of COVID-19 ICU-admitted patients including baseline characteristics, ICU and MV data, treatments complications, and outcomes. The in-hospital mortality was 31%, and 76% of patients required invasive mechanical ventilation. A 3-6 month and 1 year follow-up was performed. Few deaths after 1 year discharge were registered. Low anti-SARS-CoV-2 S antibody levels predict mortality in critical COVID-19. These antibodies contribute to prevent systemic dissemination of SARS-CoV-2. The severity of COVID-19 impacts the circulating miRNA profile. Plasma miRNA profiling emerges as a useful tool for risk-based patient stratification in critically ill COVID-19 patients. Conclusions: We present the methodology used in a large multicenter study sponsored by ISCIII to determine the short- and long-term outcomes in patients with COVID-19 admitted to more than 50 Spanish ICUs. 2022 Published by Elsevier Espafia, S.L.U. on behalf of SEPAR.

引用

页码：22 / 31

页数：10

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