Breaking old paradigms: Th17 cells in autoimmune arthritis

被引：73
|
作者：
Peck, Ariana [1 ]
Mellins, Elizabeth D. [1 ]
机构：
[1] Stanford Univ, Sch Med, Dept Pediat, Div Immunol & Transplantat Biol, Stanford, CA 94305 USA
来源：
CLINICAL IMMUNOLOGY | 2009年 / 132卷 / 03期
关键词：
Th17; IL-17; Rheumatoid arthritis; COLLAGEN-INDUCED ARTHRITIS; TUMOR-NECROSIS-FACTOR; FIBROBLAST-LIKE SYNOVIOCYTES; NF-KAPPA-B; REGULATORY T-CELLS; DIRECTLY INDUCE OSTEOCLASTOGENESIS; LEUKEMIA INHIBITORY FACTOR; TNF-ALPHA THERAPY; RHEUMATOID-ARTHRITIS; IFN-GAMMA;
D O I：
10.1016/j.clim.2009.03.522
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Aberrant helper T cell activation has been implicated in the pathogenesis of an array of autoimmune diseases. In this review, we summarize evidence that suggests the involvement of a novel T cell. subset, the Th17 lineage, in rheumatoid arthritis. In particular, we focus on the role of Th17 cells in inducing and perpetuating the chronic inflammation, cartitage damage, and bone erosion that are hallmark phases of joint destruction and consider current and emerging therapies that seek to disrupt the inflammatory Th17 network and shift the immune system back towards homeostasis. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：295 / 304
页数：10
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