Small is the new big - interplay of miRNAs in cancer

被引：0
|
作者：
Varshney, Jyotika [1 ]
Subranianian, Subbaya [1 ,2 ]
机构：
[1] Univ Minnesota, Dept Surg, Div Basic & Translat Res, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Massey Canc Ctr, Minneapolis, MN 55455 USA
来源：
CURRENT SCIENCE | 2014年 / 107卷 / 05期
关键词：
Cancer subtypes; deregulation; gene expression; microRNAs; MICRORNA EXPRESSION PROFILES; CHRONIC LYMPHOCYTIC-LEUKEMIA; GENE-EXPRESSION; CELL-PROLIFERATION; DOWN-REGULATION; PROMOTES MIGRATION; TUMOR-SUPPRESSOR; ESTROGEN-RECEPTOR; OVARIAN-CANCER; ORAL-CANCER;
D O I：
暂无
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
MicroRNAs (miRNAs) are small non-coding regulatory RNAs that post-transcriptionally regulate gene expression. About 1500 miRNAs have been discovered in humans and these can target and regulate up to 60% of coding genes. MicroRNAs play a key role in all cellular functions and are implicated in most diseases, including cancer. Deregulation of microRNA expression can affect various metabolic and signalling pathways and results in cancer development and progression. This review provides a comprehensive view of various cancer types and their associated microRNAs.
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收藏
页码：803 / 814
页数：12
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