Down-regulation of P-glycoprotein expression in MDR breast cancer cell MCF-7/ADR by honokiol

被引：90

作者：

Xu, Dong ^{[1
]}

Lu, Qinghua ^{[1
]}

Hu, Xun ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Med, Affliated Hosp 2, Inst Canc, Hangzhou 310009, Zhejiang Prov, Peoples R China

来源：

CANCER LETTERS | 2006年 / 243卷 / 02期

关键词：

honokiol; P-glycoprotein; drug resistance;

D O I：

10.1016/j.canlet.2005.11.031

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

P-glycoprotein accounts for the most intrinsic and acquired cancer multidrug resistance. To inhibit the expression of P-glycoprotein is one of the effective ways to reverse cancer drug resistance. Honokiol, a naturally occurring compound, has been demonstrated to combat cancer through mechanisms including inhibition of angiogenesis and induction of apoptosis. Here, we show that honokiol down-regulated the expression of P-glycoprotein at mRNA and protein levels in MCF-7/ADR, a human breast MDR cancer cell line. The down-regulation of P-glycoprotein was accompanied with a partial recovery of the intracellular drug accumulation, and of the sensitivities toward adriamycin. This study reveals a novel function of honokiol as an anti-cancer agent. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：274 / 280

页数：7

共 50 条

[1] Triptolide reverses MCF-7/ADR cell resistance by down-regulating P-glycoprotein expression
Zhang, Pu-Rong
Zhang, Jian-Hui
Yu, Miao
Zhang, Xin
[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2017, 10 (01): : 1513 - 1521
[2] Metformin Inhibits P-Glycoprotein Expression in Breast Cancer Cell MCF-7/ADR via Inhibition of NF-kB Activation
Thi, Hien Tran
Kim, Hyung Gyun
Jeong, Hye Gwang
[J]. DRUG METABOLISM REVIEWS, 2009, 41 : 43 - 43
[3] Rational design of phenyl thiophene (pyridine) derivatives that overcome P-glycoprotein mediated MDR in MCF-7/ADR cell
Li, Ya-Sheng
Mao, Shen
Zhao, Dong-Sheng
Wang, Can-Can
Zu, Dan
Yang, Xi
Liu, Gui-Jun
Wang, Si-Jia
Zhang, Bo
Bao, Xiao-Ze
Ye, Xin-Yi
Wei, Bin
Cui, Zi-Ning
Chen, Jian-Wei
Wang, Hong
[J]. BIOORGANIC CHEMISTRY, 2021, 114
[4] REVERSION OF MULTIDRUG RESISTANCE IN THE P-GLYCOPROTEIN POSITIVE BREAST CANCER CELL LINE(MCF-7/ADR) BY INTRODUCTION OF HAMMERHEAD RIBOZYME
袁亚维
张积仁
陆长德
祁国荣
[J]. Chinese Medical Sciences Journal, 1998, (01) : 24 - 28
[5] Lack of competition of substrates for p-glycoprotein in MCF-7 breast cancer cells overexpressing MDR1
Hall, JG
Cory, AH
Cory, JG
[J]. ADVANCES IN ENZYME REGULATION, VOL 39, 1999, 39 : 113 - 128
[6] Dolichyl phosphate dependent P-glycoprotein expression in Doxorubicin resistant MCF-7 breast cancer cells
Kuznecovs, I.
Kuznecovs, S.
Jegina, K.
Kuznecova, G.
[J]. EJC SUPPLEMENTS, 2008, 6 (09): : 86 - 86
[7] EFFECT OF P-GLYCOPROTEIN EXPRESSION ON SENSITIVITY TO HORMONES IN MCF-7 HUMAN BREAST-CANCER CELLS
CLARKE, R
CURRIER, S
KAPLAN, O
LOVELACE, E
BOULAY, V
GOTTESMAN, MM
DICKSON, RB
[J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1992, 84 (19) : 1506 - 1512
[8] Dioscin strengthens the efficiency of adriamycin in MCF-7 and MCF-7/ADR cells through autophagy induction: More than just down-regulation of MDR1
Wang, Changyuan
Huo, Xiaokui
Wang, Lijuan
Meng, Qiang
Liu, Zhihao
Liu, Qi
Sun, Huijun
Sun, Pengyuan
Peng, Jinyong
Liu, Kexin
[J]. SCIENTIFIC REPORTS, 2016, 6
[9] Dioscin strengthens the efficiency of adriamycin in MCF-7 and MCF-7/ADR cells through autophagy induction: More than just down-regulation of MDR1
Changyuan Wang
Xiaokui Huo
Lijuan Wang
Qiang Meng
Zhihao Liu
Qi Liu
Huijun Sun
Pengyuan Sun
Jinyong Peng
Kexin Liu
[J]. Scientific Reports, 6
[10] ALLOSTERIC REGULATION OF [H-3] VINBLASTINE BINDING TO P-GLYCOPROTEIN OF MCF-7 ADR CELLS BY DEXNIGULDIPINE
FERRY, DR
MALKHANDI, PJ
RUSSELL, MA
KERR, DJ
[J]. BIOCHEMICAL PHARMACOLOGY, 1995, 49 (12) : 1851 - 1861

← 1 2 3 4 5 →