Detection of circulating tumor cells in bladder cancer patients

被引：30

作者：

Nezos, Adrianos ^{[1
]}

Pissimisis, Nikolaos ^{[1
,2
]}

Lembessis, Peter ^{[1
,2
]}

Sourla, Antigone ^{[1
,2
]}

Dimopoulos, Peter ^{[3
]}

Dimopoulos, Theodore

Tzelepis, Kostantinos ^{[1
]}

Koutsilieris, Michael ^{[1
]}

机构：

[1] Univ Athens, Dept Expt Physiol, Sch Med, Athens 11527, Greece

[2] Endo Oncores Med Lab, Athens, Greece

[3] PANAGIA Gen Hosp, Div Urol, Thessaloniki, Greece

来源：

CANCER TREATMENT REVIEWS | 2009年 / 35卷 / 03期

关键词：

Circulating bladder cancer cells; Molecular markers; Clinical significance; POLYMERASE-CHAIN-REACTION; TRANSCRIPTASE MESSENGER-RNA; GROWTH-FACTOR RECEPTOR; VOIDED URINE SAMPLES; ANTI-APOPTOSIS GENE; METASTATIC BREAST-CANCER; HUMAN TELOMERASE RNA; PERIPHERAL-BLOOD; MOLECULAR-DETECTION; UROTHELIAL CANCER;

D O I：

10.1016/j.ctrv.2008.11.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The methods employed for the detection of circulating bladder cancer cells (CBCs) and their use as a molecular staging too[ in clinical settings are thoroughly reviewed. CBC isolation and enrichment methods are discussed according to their advantages and pitfalls along with the clinical data of PCR-based techniques used for CBC detection. In addition, we review the specificity of molecular markers that have been proposed so far for CBC identification. and we comment on the controversial clinical data, proposing laboratory approaches which may improve the clinical significance of CBC detection in bladder cancer. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：272 / 279

页数：8

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