Sex differences in cognitive impairment and Alzheimer's disease

被引：356
|
作者：
Li, Rena [1 ]
Singh, Meharvan [2 ]
机构：
[1] Roskamp Inst, Ctr Hormone Adv Sci & Educ, Sarasota, FL 34243 USA
[2] Univ N Texas, Hlth Sci Ctr, Ctr FOR HER, Dept Pharmacol & Neurosci,Inst Aging & Alzheimers, Ft Worth, TX 76107 USA
来源：
FRONTIERS IN NEUROENDOCRINOLOGY | 2014年 / 35卷 / 03期
基金：
美国国家卫生研究院;
关键词：
Gender; Sex difference; Steroid hormones; Cognition; Alzheimer's disease; ESTROGEN-REPLACEMENT THERAPY; ACTIVATED PROTEIN-KINASE; CONJUGATED EQUINE ESTROGENS; CEREBRAL-ARTERY OCCLUSION; TRAUMATIC BRAIN-INJURY; MENTAL ROTATION PERFORMANCE; THROMBOSPONDIN-4 A387P POLYMORPHISM; NATIONAL COMORBIDITY SURVEY; HEALTH INITIATIVE MEMORY; BETA-ESTRADIOL PROTECTS;
D O I：
10.1016/j.yfrne.2014.01.002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Studies have shown differences in specific cognitive ability domains and risk of Alzheimer's disease between the men and women at later age. However it is important to know that sex differences in cognitive function during adulthood may have their basis in both organizational effects, i.e., occurring as early as during the neuronal development period, as well as in activational effects, where the influence of the sex steroids influence brain function in adulthood. Further, the rate of cognitive decline with aging is also different between the sexes. Understanding the biology of sex differences in cognitive function will not only provide insight into Alzheimer's disease prevention, but also is integral to the development of personalized, gender-specific medicine. This review draws on epidemiological, translational, clinical, and basic science studies to assess the impact of sex differences in cognitive function from young to old, and examines the effects of sex hormone treatments on Alzheimer's disease in men and women. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码：385 / 403
页数：19
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