Clinical Trials of Adult Stem Cell Therapy in Patients with Ischemic Stroke

被引：58
|
作者：
Bang, Oh Young [1 ,2 ]
机构：
[1] Sungkyunkwan Univ, Samsung Med Ctr, Dept Neurol, Sch Med, Seoul 06351, South Korea
[2] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Translat & Stem Cell Res Lab Stroke, Seoul, South Korea
来源：
JOURNAL OF CLINICAL NEUROLOGY | 2016年 / 12卷 / 01期
关键词：
stroke; clinical trials; stem cells; MARROW MONONUCLEAR-CELLS; EMERGING PARADIGM; RANDOMIZED-TRIAL; STROMAL CELLS; TRANSPLANTATION; BRAIN; NEUROTRANSPLANTATION; SCIENCE; DISEASE; BENEFIT;
D O I：
10.3988/jcn.2016.12.1.14
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Stem cell therapy is considered a potential regenerative strategy for patients with neurologic deficits. Studies involving animal models of ischemic stroke have shown that stem cells transplanted into the brain can lead to functional improvement. With current advances in the understanding regarding the effects of introducing stem cells and their mechanisms of action, several clinical trials of stem cell therapy have been conducted in patients with stroke since 2005, including studies using mesenchymal stem cells, bone marrow mononuclear cells, and neural stem/progenitor cells. In addition, several clinical trials of the use of adult stem cells to treat ischemic stroke are ongoing. This review presents the status of our understanding of adult stem cells and results from clinical trials, and introduces ongoing clinical studies of adult stem cell therapy in the field of stroke.
引用
收藏
页码：14 / 20
页数：7
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