MIC6 associates with aldolase in host cell invasion by Toxoplasma gondii

被引：28
|
作者：
Zheng, Bin [1 ]
He, Ai [1 ]
Gan, Ming [1 ]
Li, Zhouya [1 ]
He, Hualiang [1 ]
Zhan, Ximei [1 ]
机构：
[1] Sun Yat Sen Univ, Dept Parasitol, Zhongshan Sch Med, Guangzhou 510080, Guangdong, Peoples R China
来源：
PARASITOLOGY RESEARCH | 2009年 / 105卷 / 02期
关键词：
MICRONEMAL PROTEINS; ACTIN CYTOSKELETON; GLIDING MOTILITY; BINDING; MYOSIN; IDENTIFICATION; ADHESION; DOMAIN;
D O I：
10.1007/s00436-009-1401-5
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
The transmembrane microneme protein MIC6 and its partner MIC1, MIC4 comprise an adhesive complex that play important roles in host cell attachment by the obligate intracellular parasite Toxoplasma gondii. Successful penetration of host cells by T. gondii depends on coordinated interactions between MICs complex and the parasite's cytoskeleton. We have identified that the carboxy-terminal cytoplasmic domain (C domain) of MIC6 interacts with aldolase and the parasite cytoskeleton. Our finding uncovers new features regarding MIC6-aldolase interactions in host cell invasion by T. gondii.
引用
收藏
页码：441 / 445
页数：5
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