Confinement and controlled release of bisphosphonates on ordered mesoporous silica-based materials

被引：363
|
作者：
Balas, Francisco [1 ]
Manzano, Miguel [1 ]
Horcajada, Patricia [1 ]
Vallet-Regi, Maria [1 ]
机构：
[1] Univ Complutense Madrid, Fac Farm, Dept Quim Inorgan & Bioinorgan, E-28040 Madrid, Spain
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 25期
关键词：
D O I：
10.1021/ja062286z
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Bisphosphonates have been confined in siliceous ordered mesoporous materials, and the drug release rate of these systems has been investigated. The bisphosphonate adsorption rate has been increased from 1% in oral administration to around 40% locally delivered. Drug dosage can be modulated through amine modification of the material surface, leading to a bisphosphonate adsorption in the ordered mesoporous matrices 3 times larger than that for unmodified materials. The use of these drug delivery systems opens new fields with new possibilities for tissue engineering. Copyright © 2006 American Chemical Society.
引用
收藏
页码：8116 / 8117
页数：2
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