Diagnosis, Prognosis and Therapeutic Role of Circulating miRNAs in Cardiovascular Diseases

被引:110
|
作者
Sayed, Ali Sheikh Md [1 ]
Xia, Ke [1 ,2 ]
Salma, Umme [3 ]
Yang, Tianlun [1 ]
Peng, Jun [4 ]
机构
[1] Cent South Univ, Xiangya Hosp, Dept Cardiol, Changsha 410078, Hunan, Peoples R China
[2] Harvard Univ, Sch Med, Ctr Vasc Biol & Inflammat, Brigham & Womens Hosp,Dept Med,Cardiovasc Div, Boston, MA 02115 USA
[3] Cent South Univ, Xiangya Hosp 3, Dept Obstet & Gynecol, Changsha 410013, Hunan, Peoples R China
[4] Cent South Univ, Sch Pharmaceut Sci, Dept Pharmacol, Changsha 410078, Hunan, Peoples R China
来源
HEART LUNG AND CIRCULATION | 2014年 / 23卷 / 06期
基金
国家教育部博士点专项基金资助;
关键词
Cardiovascular disease (CVD); Circulating miRNAs; Biomarkers; Prognosis; Treatment; MYOCARDIAL-INFARCTION; MICRORNA EXPRESSION; CARDIAC-FUNCTION; GENE-EXPRESSION; HEART-FAILURE; SERUM; BIOMARKERS; HYPERTENSION; BLOOD; OVEREXPRESSION;
D O I
10.1016/j.hlc.2014.01.001
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in the world. Although much progress has been made for cardiovascular diseases in diagnosis, treatment and prognosis during the past two decades, the clinical need for a novel diagnostic biomarker and new therapeutic interventions to decrease the cardiovascular disease incidence is ongoing. MicroRNAs (miRNAs) are endogenous, small (similar to 22 nucleotides), single-stranded, non-coding RNAs that regulate gene expression and are detectable in whole blood, serum, plasma, urine and other body fluids in a highly stable form. Accumulating evidence suggests that miRNAs are potential novel biomarkers with high sensitivity for early diagnosis and modern treatment for cardiovascular diseases. Altered circulating miRNAs expressions have been reported in acute myocardial infarction (AMI), acute coronary syndrome (ACS), stable coronary artery disease, heart failure, atherosclerosis, essential hypertension and stroke. In the present review, we examine more recent data regarding circulating miRNAs and their potential roles in diagnosis, prognosis and therapeutic strategies for cardiovascular diseases. In addition, we briefly present our own recent experience in detecting circulating miRNAs, and the significance of these miRNAs in AMI prognosis.
引用
收藏
页码:503 / 510
页数:8
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