Synthetic construction of a Lex determinant via gabriel amine synthesis and the glycopolymer involving highly clustered Lex residues

被引：14

作者：

Matsuoka, Koji ^{[1
]}

Kohzu, Tatsuya ^{[1
]}

Hakumura, Takashi ^{[1
]}

Koyama, Tetsuo ^{[1
]}

Hatano, Ken ^{[1
]}

Terunuma, Daiyo ^{[1
]}

机构：

[1] Saitama Univ, Grad Sch Sci & Engn, Div Mat Sci, Area Mol Funct,Sakura Ku, Saitama 3388570, Japan

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 21期

关键词：

Lewis x; Glycosides; Gabriel synthesis; Glycopolymers; Glycoclusters; ACETYL-D-GLUCOSAMINE; ANTIGEN; OLIGOSACCHARIDES; RECOGNITION; BINDING; TRISACCHARIDE; GLOBOTRIAOSE; DERIVATIVES; GLYCOSIDES; SEQUENCE;

D O I：

10.1016/j.tetlet.2009.03.099

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthetic construction of a Le(x) determinant was accomplished via slightly modified Gabriel amine synthesis from three building blocks. Further transformations followed by polymerization of the Le(x) derivative gave a glycopolymer having trisaccharidic units as pendant-type epitopes. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2593 / 2596

页数：4

共 3 条

[1] Synthetic construction of a fucosyl chitobiose as an allergen-associated carbohydrate epitope and the glycopolymer involving highly clustered trisaccharidic sequences
Matsuoka, Koji
Yamaguchi, Hiroki
Koyama, Tetsuo
Hatano, Ken
Terunuma, Daiyo
[J]. TETRAHEDRON LETTERS, 2010, 51 (18) : 2529 - 2532
[2] A highly efficient synthetic strategy for polymeric support synthesis of Lex, Ley, and H-type 2 oligosaccharides
Zhu, T
Boons, GJ
[J]. CHEMISTRY-A EUROPEAN JOURNAL, 2001, 7 (11) : 2382 - 2389
[3] CHIRAL SYNTHESIS OF POLYKETIDE-DERIVED NATURAL PRODUCTS .47. SYNTHETIC STUDIES OF HALICHONDRIN-B, AN ANTITUMOR POLYETHER MACROLIDE ISOLATED FROM A MARINE SPONGE .2. EFFICIENT SYNTHESIS OF C16-C26 FRAGMENTS VIA CONSTRUCTION OF THE D-RING BY A HIGHLY STEREOCONTROLLED IODOETHERIFICATION
HORITA, K
NAGASAWA, M
HACHIYA, S
YONEMITSU, O
[J]. SYNLETT, 1994, (01) : 40 - 43

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